Table 2

Relation of TS and MTHFR polymorphisms and geometric mean levels of plasma folate and tHcy in the Physicians’ Health Study

GenotypeFolate (ng/ml)tHcy (nmol/ml)
nMeanPnMeanP
TSpromoter
3R/3R1696.24(referent)14611.5(referent)
3R/2R2625.790.2322211.70.64
2R/2R1145.290.039911.50.96
TS 5′-UTR
 +6bp/+6bp2385.62(referent)20211.6(referent)
 +6bp/−6bp2346.000.2620211.60.98
 −6bp/−6bp726.050.396111.40.70
MTHFR
CC2216.19(referent)21411.4(referent)
CT1995.790.2419211.40.87
TT615.100.035812.80.03
TS-MTHFR
3R/3R-CC747.06(referent)6511.8(referent)
2R/3R-CC1126.250.2010111.20.33
2R/2R-CC466.200.284410.50.09
3R/3R-CT646.430.386010.70.11
2R/3R-CT1126.460.369411.60.75
2R/2R-CT445.420.033912.00.81
3R/3R-TT226.140.371911.30.63
2R/3R-TT284.63<0.0012513.30.18
2R/2R-TT156.260.501312.60.56
  • a Geometric means adjusted for age.

  • b Test for linear trend on the continuous log-transformed plasma folate and total homocysteine levels.