Table 1

Association of TS polymorphisms and risk of colorectal cancer in the Physicians’ Health Study

GenotypeNo. cases (%)No. controls (%)RRa (95% confidence interval)P trend
TSpromoter polymorphism
3R/3R87 (32)132 (29)(referent)
2R/3R135 (50)218 (48)0.86 (0.59–1.25)
2R/2R48 (18)104 (23)0.59 (0.36–0.98)0.03
TS 3′-UTRpolymorphism
 +6bp/+6bp124 (46)201 (44)(referent)
 +6bp/−6bp113 (42)191 (42)0.82 (0.59–1.16)
 −6bp/−6bp33 (12)62 (14)0.81 (0.47–1.38)0.28
  • a Relative risk from conditional regression model with matching variables of age, aspirin assignment groups, and use of cigarettes and multivitamins.