Association of TS polymorphisms and risk of colorectal cancer in the Physicians’ Health Study
| Genotype | No. cases (%) | No. controls (%) | RRa (95% confidence interval) | P trend |
|---|---|---|---|---|
| TSpromoter polymorphism | ||||
| 3R/3R | 87 (32) | 132 (29) | (referent) | |
| 2R/3R | 135 (50) | 218 (48) | 0.86 (0.59–1.25) | |
| 2R/2R | 48 (18) | 104 (23) | 0.59 (0.36–0.98) | 0.03 |
| TS 3′-UTRpolymorphism | ||||
| +6bp/+6bp | 124 (46) | 201 (44) | (referent) | |
| +6bp/−6bp | 113 (42) | 191 (42) | 0.82 (0.59–1.16) | |
| −6bp/−6bp | 33 (12) | 62 (14) | 0.81 (0.47–1.38) | 0.28 |
a Relative risk from conditional regression model with matching variables of age, aspirin assignment groups, and use of cigarettes and multivitamins.