Joint effect of hOGG1 codon 326 and XRCC1 codon 280 and NPC risk
| Gene-gene grouping hOGG1 codon 326 | XRCC1 codon 280 | NPC case patients | Community control subjects | Unadjusted OR | Adjusteda OR (95% CI) |
|---|---|---|---|---|---|
| Ser/Ser | Arg/His + His/His | 5 | 11 | 1.0 | 1.0 |
| Ser/Ser | Arg/Arg | 31 | 35 | 1.9 | 1.9 (0.59–6.2) |
| Ser/Cys + Cys/Cys | Arg/His + His/His | 52 | 57 | 2.0 | 2.0 (0.63–6.1) |
| Ser/Cys + Cys/Cys | Arg/Arg | 243 | 180 | 3.0b | 3.0 (1.0–8.8) |
a OR estimates adjusted for age, gender, and ethnicity.
b Indicates unadjusted ORs in which 95% CI excludes 1.0.