Table 5

Associations of breast cancer with combined IGF and steroid hormones among postmenopausal womena

VariableIGF-IIGF-IIIGFBP-3
No.bOR (95% CI)No.OR (95% CI)No.OR (95% CI)
Testosterone
 Low/lowc35/241.0030/211.0032/201.00
 High/low30/311.67 (0.78–3.61)35/351.35 (0.60–3.07)33/291.63 (0.71–3.72)
 Low/high30/231.05 (0.46–2.41)35/261.18 (0.39–3.54)33/271.31 (0.55–3.12)
 High/high35/482.15 (1.02–4.50)30/443.06 (1.10–8.53)32/502.68 (1.18–6.06)
Estrone
 Low/low33/221.0025/181.0039/221.00
 High/low31/321.84 (0.86–3.97)38/371.71 (0.67–4.36)26/272.13 (0.94–4.83)
 Low/high31/271.22 (0.54–2.77)39/311.48 (0.47–4.70)25/271.70 (0.75–3.88)
 High/high33/442.19 (1.06–4.56)26/392.77 (1.00–7.63)38/492.63 (1.21–5.73)
Estradiol
 Low/low35/221.0022/201.0041/271.00
 High/low30/331.88 (0.73–4.82)43/360.99 (0.39–2.58)24/221.62 (0.62–4.25)
 Low/high29/351.93 (0.84–4.43)42/371.28 (0.43–3.82)23/301.77 (0.86–3.61)
 High/high36/361.67 (0.70–3.98)23/332.24 (0.74–6.81)42/472.23 (0.84–5.93)
Estrone-S
 Low/low30/231.0043/291.0020/171.00
 High/low35/321.30 (0.60–2.82)22/272.02 (0.87–4.70)45/320.63 (0.25–1.58)
 Low/high35/321.27 (0.60–2.69)22/262.62 (0.96–7.17)45/380.80 (0.34–1.88)
 High/high30/391.72 (0.78–3.79)43/442.33 (0.86–6.29)20/391.78 (0.74–4.25)
DHEA-S
 Low/low39/281.0035/251.0034/211.00
 High/low26/271.50 (0.74–3.04)30/311.41 (0.67–2.96)31/281.63 (0.73–3.62)
 Low/high26/241.37 (0.65–2.89)30/271.79 (0.64–4.97)31/311.81 (0.79–4.15)
 High/high39/471.72 (0.84–3.50)35/432.47 (0.93–6.57)34/462.07 (0.99–4.35)
  • a Unadjusted conditional logistic regression analysis.

  • b Number of control versus number of case.

  • c Low/low, low steroids and low IGF-I or IGFBP-3; High/low, high steroids and low IGF-I or IGFBP-3; Low/high, low steroids and high IGF-I or IGFBP-3; High/high, high steroids and high IGF-I or IGFBP-3; Low, lower than median; High, higher than or equal to median.