Table 3

Associations of breast cancer with IGFs and steroid hormonesa

Variable1st quartileb (Reference)2nd quartile OR (95% CI)3rd quartile OR (95% CI)4th quartile OR (95% CI)P for trendMedian cutoff
Premenopausal women
 IGF-I1.001.41 (0.72–2.77)1.48 (0.72–3.06)2.66 (1.40–5.05)0.0031.78c
 IGF-II1.001.88 (0.86–4.11)1.15 (0.41–3.28)1.69 (0.61–4.73)0.3780.82
 IGFBP-31.001.17 (0.57–2.39)2.17 (1.05–4.46)4.26 (1.89–9.63)<0.0012.56c
 Estradiol1.000.61 (0.31–1.18)0.62 (0.33–1.15)0.68 (0.37–1.26)0.2650.83
 Estrone1.001.02 (0.52–2.03)1.44 (0.75–2.79)1.46 (0.78–2.76)0.1491.44
 Estrone-S1.001.00 (0.53–1.91)0.97 (0.47–1.99)1.21 (0.65–2.27)0.5141.11
 Testosterone1.001.38 (0.62–3.06)1.17 (0.51–2.66)2.92 (1.27–6.70)0.0091.46
 DHEA-S1.000.80 (0.42–1.53)0.92 (0.48–1.74)1.43 (0.77–2.68)0.1870.85
 SHBG1.000.76 (0.39–1.48)0.73 (0.37–1.43)0.73 (0.36–1.49)0.4180.91
 Progesterone1.001.38 (0.70–2.72)1.25 (0.62–2.55)0.82 (0.40–1.70)0.450
Postmenopausal women
 IGF-I1.001.34 (0.61–2.96)1.05 (0.44–2.52)2.11 (0.92–4.86)0.1081.29
 IGF-II1.000.89 (0.46–1.72)1.63 (0.68–3.90)2.21 (0.70–6.96)0.2591.78
 IGFBP-31.001.17 (0.58–2.39)1.43 (0.71–2.89)2.86 (1.02–7.99)0.0591.55
 Estrone1.000.81 (0.33–1.98)0.82 (0.35–1.93)2.67 (1.17–6.07)0.0071.79c
 Estrone-S1.000.56 (0.22–1.41)1.41 (0.56–3.57)0.72 (0.31–1.68)1.0001.32
 Testosterone1.000.58 (0.25–1.35)1.04 (0.47–2.33)1.87 (0.84–4.20)0.0341.89c
 DHEA-S1.001.89 (0.87–4.11)1.27 (0.61–2.65)2.92 (1.28–6.67)0.0371.40
 SHBG1.001.00 (0.46–2.19)0.86 (0.39–1.88)0.79 (0.36–1.74)0.4870.92
  • a Unadjusted conditional logistic regression analysis.

  • b Lowest quartile.

  • c P < 0.05.