Table 1

Plasma levels of IGFs and steroid hormones in breast cancer patients and controls

VariableCaseControlPa
Premenopausal women
 IGF-I (ng/ml)163 (133, 201)b146 (118, 179)b0.018
 IGF-II (ng/ml)852 (688, 1043)867 (653, 999)0.248
 IGFBP-3 (ng/ml)4224 (3693, 5046)3901 (3377, 4510)0.009
 Estradiol (pg/ml)41.1 (23.1, 74.2)45.3 (28.0, 74.0)0.507
 Estrone (pg/ml)32.8 (23.5, 52.5)28.9 (21.4, 42.3)0.348
 Estrone-S (pg/ml)1412 (445, 3811)1408 (415, 3400)0.920
 Testosterone (pg/ml)207 (143, 294)189 (133, 250)0.036
 DHEA-S (ng/ml)907 (622, 1335)826 (610, 1091)0.300
 SHBG (nmol/ml)71.2 (42.2, 118.3)73.9 (48.0, 121.0)0.772
 Progesterone (pg/ml)1200 (600, 4500)1200 (600, 5700)0.498
Postmenopausal women
 IGF-I (ng/ml)114 (91, 158)106 (87, 131)0.302
 IGF-II (ng/ml)867 (676, 1049)810 (667, 1016)0.848
 IGFBP-3 (ng/ml)4596 (3946, 5692)4189 (3686, 5307)0.316
 Estrone (pg/ml)19.6 (9.6, 25.4)17.7 (9.1, 20.7)0.004
 Estrone-S (pg/ml)1214 (456, 6677)978 (464, 7262)0.282
 Testosterone (pg/ml)199 (124, 282)161 (121, 217)0.034
 DHEA-S (ng/ml)680 (487, 1011)611 (410, 828)0.152
 SHBG (nmol/ml)73.1 (51.3, 108.0)74.5 (53.8, 116.3)0.198
  • a χ2 test based on the quartile distributions between cases and controls.

  • b Values represent median (25th, 75th percentile).