Table 3

Relationship between alcohol use and risk of breast cancer by ER and PR status

FactorControls n = 998ER+ n = 789ORa95% CIER− n = 106OR95% CIPR+ n = 648OR95% CIPR− n = 244OR95% CI
N%N%N%N%N%
Alcohol use (g/day)
 Never51451.537047.01.0(ref)5350.01.0(ref)30046.31.0(ref)12249.81.0(ref)
 Ever48448.541953.11.3(1.0–1.6)b5350.01.1(0.7–1.7)34853.71.3(1.1–1.7)b12250.01.1(0.8–1.4)
  <1.5595.9486.11.2(0.8–1.8)65.71.1(0.4–2.7)416.31.2(0.8–1.9)135.31.0(0.5–1.9)
  1.5–4.912112.210913.81.6(1.0–1.8)1211.31.1(0.5–2.1)9214.21.4(1.0–2.0)b2911.91.0(0.6–1.6)
  5.0–14.916716.613316.91.2(0.9–1.6)1817.01.0(0.6–1.9)10716.51.2(0.9–1.6)4317.61.1(0.7–1.6)
  15.0–29.9919.2769.61.2(0.9–1.8)1211.31.4(0.7–2.7)6510.01.3(0.9–1.9)229.01.1(0.6–1.8)
  ≥30.0464.6536.71.7(1.1–2.7)b54.71.2(0.5–3.2)436.61.8(1.1–2.8)b156.11.4(0.7–2.7)
  P for trend0.7050.5440.9980.702
 Former777.7577.21.1(0.8–1.7)87.51.1(0.5–2.5)477.31.2(0.8–1.8)187.41.0(0.6–1.8)
 Current40740.836245.91.3(1.1–1.6)b4542.51.1(0.7–1.8)30146.51.4(1.1–1.7)b10442.61.1(0.8–1.5)
  <1.5676.7617.71.3(0.9–1.8)109.41.5(0.7–3.2)507.71.3(0.9–1.9)218.61.3(0.8–2.2)
  1.5–4.9878.7769.61.3(0.9–1.8)87.51.0(0.4–2.1)6710.31.4(1.0–2.1)b177.00.8(0.5–1.4)
  5.0–14.913813.811414.41.2(0.9–1.7)109.40.8(0.4–1.6)9414.51.3(0.9–1.8)2911.90.9(0.5–1.4)
  15.0–29.9787.8617.71.2(0.8–1.7)1211.31.5(0.7–3.0)507.71.2(0.8–1.8)229.01.2(0.7–2.1)
  ≥30.0373.7506.31.9(1.2–3.1)b54.71.5(0.5–4.0)406.22.0(1.2–3.2)b156.11.7(0.9–3.3)
  P for trend0.3860.9020.5080.462
Alcohol use (g/day)
 Never51451.529846.41.0(ref)7149.31.0(ref)5151.01.0(ref)
 Ever48448.534453.61.3(1.1–1.7)b7350.71.1(0.7–1.5)4949.01.1(0.7–1.7)
  <1.5595.9416.41.2(0.8–1.9)74.90.9(0.4–2.1)66.01.1(0.5–2.7)
  1.5–4.912112.29014.01.4(1.0–2.0)b1913.21.0(0.6–1.8)1010.00.9(0.4–1.9)
  5.0–14.916716.610616.51.2(0.9–1.6)2618.11.1(0.7–1.9)1717.01.0(0.5–1.8)
  15.0–29.9919.26410.01.3(0.9–1.9)117.60.9(0.4–7.8)1111.01.3(0.6–2.6)
  ≥30.0464.6436.71.8(1.1–2.8)b106.91.5(0.7–3.3)55.01.2(0.5–3.3)
  P for trend0.9450.3300.656
 Former777.7467.21.2(0.8–1.8)117.61.1(0.5–2.2)77.00.9(0.4–2.3)
 Current40740.829846.41.4(1.1–1.7)b6243.11.1(0.7–1.6)4242.01.1(0.7–1.7)
  <1.5676.7507.81.3(0.9–1.9)117.61.1(0.5–2.3)1010.01.6(0.7–3.3)
  1.5–4.9878.76410.01.4(1.0–2.0)b128.31.0(0.5–1.9)55.00.6(0.2–1.6)
  5.0–14.913813.89414.61.3(0.9–1.8)1913.20.9(0.5–1.7)1010.00.8(0.4–1.6)
  15.0–29.9787.8507.81.2(0.8–1.8)106.91.0(0.5–2.1)1212.01.5(0.7–3.1)
  ≥30.0373.7406.22.0(1.2–3.3)b106.91.8(0.8–4.0)55.01.5(0.6–4.1)
  P for trend0.4390.5480.367
  • a All odds ratios (ORs) are adjusted for age (continuous), family history of breast cancer (yes/no), and body mass index (quartiles).

  • b P < 0.05