Table 3

The risk for multiple-field cancerization in esophageal and oropharyngolaryngeal SCC patients

OR for multiple cancer (95% CI)
Esophageal SCCOropharyngolaryngeal SCC
Age (per 10 years)0.96 (0.52–1.79)0.97 (0.48–1.96)
Smoking, pack-yearsa
 <4111
 ≥411.09 (0.34–3.47)1.20 (0.21–7.39)
Current drinking, drinks/dayb
 <311
 3–5.91.01 (0.15–8.26)2.96 (0.28–38.44)
 ≥61.27 (0.18–10.94)1.21 (0.13–12.37)
Former drinking2.27 (0.21–28.06)1.23 (0.09–18.74)
ALDH2*1/2*1 11
ALDH2*1/2*2 or 2*2/2*25.26 (1.08–51.06)7.36 (1.29–80.70)
  • a For this analysis, pack-years were divided at the median.

  • b 1 drink = 12 g of ethanol.