Table 2

Age, drinking, and smoking habits and ALDH2 genotype in esophageal and oropharyngolaryngeal SCC patients with and without multiple-field cancerization

Risk factorsEsophageal SCCOropharyngolaryngeal SCC
Multiplicity absentMultiplicity presentMultiplicity absentMultiplicity present
(n = 48) No. of cases(n = 26)a No. of cases(n = 29) No. of cases(n = 17)a No. of cases
Age (mean ± SD)63 ± 961 ± 861 ± 1361 ± 10
Current smokers29 (60.4%)19 (73.1%)23 (79.3%)10 (58.8%)
Ex-smokers17 (35.4%)5 (19.2%)6 (20.7%)5 (29.4%)
Never smokers2 (4.2%)2 (7.7%)0 (0%)2 (11.8%)
Pack-years (mean ± SD)46.4 ± 24.343.9 ± 26.951.4 ± 23.444.9 ± 29.7
Current drinkers44 (91.7%)22 (84.6%)25 (86.2%)14 (82.4%)
Ex-drinkers4 (8.3%)4 (15.4%)4 (13.8%)3 (17.6%)
Drinks/dayb
 <39 (18.8%)3 (11.5%)6 (20.7%)3 (17.6%)
 3–5.917 (35.4%)8 (30.8%)6 (20.7%)6 (35.3%)
 ≥618 (37.5%)11 (42.3%)13 (44.8%)5 (29.4%)
ALDH2*1/2*1 16 (33.3%)2 (7.7%)15 (51.7%)2 (11.8%)
ALDH2*1/2*2 or ALDH2*2/2*2 32 (66.7%)24 (92.3%)c14 (48.3%)15 (88.2%)c
  • a Thirteen patients had both esophageal SCCs and oropharyngolaryngeal SCCs. The total number of patients is 107.

  • b 1 drink = 12 g of ethanol.

  • c P < 0.05 by Fisher’s exact test.