Table 2

Difference in distribution of CYP2A6 genotypes in lung cancer patients

GenotypeCase (n = 370)Control (n = 380)Unadjusted OR (95% CI)Adjusted OR (95% CI)a
*1A/*1A 80 (21.3%)54 (14.2%)1.001.00
*1A/*1B 127 (34.6%)123 (32.4%)0.70 (0.46–1.07)0.68 (0.44–1.06)
*1B/*1B 60 (16.2%)67 (17.6%)0.60 (0.37–0.99)b0.56 (0.34–0.93)b
*1A/*4 43 (11.6%)51 (13.4%)0.57 (0.33–0.97)b0.59 (0.34–1.02)
*1B/*4 55 (14.9%)66 (17.4%)0.56 (0.34–0.92)b0.59 (0.35–0.97)b
*4/*4 5 (1.4%)19 (5.0%)0.18 (0.06–0.50)b0.23 (0.08–0.67)b
  • a Age and smoking amount were adjusted in this analysis. *1A, CYP2A6*1A; *1B, CYP2A6*1B; *4, CYP2A6*4.

  • b Significant decrease in OR is indicated by 95% CI.