Table 4

Level of DNA strand breaks, ENDOIII- and FPG-sensitive sites, and hydrogen peroxide sensitivity in mononuclear blood cells detected by the comet assay (mean and SD) a,b

DietBeforeDay 9Day 16Day 24Afterc
Strand breaks
 Placebo26.6 ± 13.325.4 ± 18.726.8 ± 15.023.2 ± 12.833.0 ± 13.5
 Vitamin29.8 ± 12.823.4 ± 12.032.3 ± 15.727.8 ± 14.633.3 ± 12.3
 Vegetable25.1 ± 13.430.1 ± 13.034.1 ± 25.625.6 ± 14.128.1 ± 16.9
ENDOIII sensitive sites
 Placebo27.0 ± 24.532.1 ± 20.121.6 ± 22.027.8 ± 23.420.3 ± 17.3
 Vitamin33.2 ± 15.732.3 ± 24.923.5 ± 14.820.3 ± 26.532.2 ± 10.0
 Vegetable36.5 ± 14.429.5 ± 15.431.4 ± 26.527.3 ± 18.822.0 ± 26.2
FPG-sensitive sites
 Placebo42.2 ± 25.339.9 ± 29.435.9 ± 15.744.9 ± 25.335.7 ± 19.6
 Vitamin28.9 ± 28.137.6 ± 29.131.2 ± 18.833.9 ± 18.436.5 ± 20.1
 Vegetable38.3 ± 19.636.2 ± 22.239.5 ± 26.339.7 ± 23.135.3 ± 26.2
Hydrogen peroxide-sensitive sites
 Placebo33.6 ± 10.628.4 ± 15.945.6 ± 18.131.4 ± 12.335.0 ± 14.0
 Vitamin39.3 ± 12.537.7 ± 13.142.3 ± 15.634.3 ± 10.637.3 ± 16.4
 Vegetable36.7 ± 16.441.1 ± 16.545.6 ± 26.737.7 ± 10.840.9 ± 19.7
  • a The data are expressed as arbitrary units.

  • b There were no interaction between the diets consumed and time-point in the study. For strand breaks, ENDOIII, and FPG-sensitive sites there were no statistically significant effects of the diet consumed or the time point in the study.

  • c The “after” samples were obtained 4 weeks after cessation of the intervention period (day 52).