Table 3

Adjusted ORs and 95% CIs for the association of breast cancer with urinary excretion of phytoestrogens, Shanghai, 1996–1998

ORs for urinary phytoestrogen excretion (by tertile)a
T1T2T3P for trend
All subjects (250 pairs)
 Total isoflavonoidsb1.000.69 (0.44–1.08)0.62 (0.39–0.99)0.04
  Parent compounds1.000.53 (0.34–0.83)0.56 (0.35–0.90)0.01
    Daidzein1.000.52 (0.33–0.81)0.54 (0.34–0.85)<0.01
    Genistein1.000.90 (0.57–1.40)0.65 (0.41–1.03)0.07
    Glycitein1.000.42 (0.27–0.66)0.42 (0.25–0.70)<0.01
  Metabolites1.000.57 (0.36–0.89)0.64 (0.41–1.02)0.04
    O-DMA1.000.64 (0.40–1.01)0.72 (0.45–1.16)0.15
    Dihydrodaidzein1.000.41 (0.25–0.66)0.73 (0.47–1.14)0.08
    Dihydrogenistein1.000.55 (0.35–0.87)0.57 (0.36–0.90)0.01
 Lignans1.000.49 (0.31–0.79)0.40 (0.24–0.64)<0.01
  Enterolactone1.000.72 (0.46–1.13)0.42 (0.25–0.69)<0.01
  Enterodiol1.000.70 (0.45–1.10)0.43 (0.26–0.71)<0.01
 Citrus flavonoids1.000.71 (0.44–1.15)1.04 (0.66–1.63)0.86
  Hesperetin1.000.46 (0.28–0.75)0.87 (0.54–1.39)0.42
  Naringenin1.000.76 (0.48–1.19)1.02 (0.66–1.60)0.92
Premenopausal women (132 pairs)
 Total isoflavonoidsb1.000.65 (0.33–1.29)0.72 (0.36–1.44)0.33
 Lignans1.000.34 (0.16–0.69)0.24 (0.12–0.50)<0.01
 Citrus flavonoids1.000.73 (0.37–1.41)1.53 (0.77–3.04)0.27
Postmenopausal women (118 pairs)
 Total isoflavonoidsb1.000.76 (0.40–1.46)0.54 (0.28–1.06)0.07
 Lignans1.000.60 (0.30–1.17)0.62 (0.31–1.26)0.16
 Citrus flavonoids1.000.75 (0.35–1.61)0.79 (0.41–1.51)0.51
  • a Adjusted for age at first live birth, ever diagnosed with fibroadenoma, total meat intake, and physical activity level.

  • b Include daidzein, genistein, glycitein, O-DMA, dihydrodaidzein, and dihydrogenistein.