Table 1

Intermediate marker status by selected characteristics of study subjects

	Histology			Flow cytometry							Allelic loss
		HGD			Increased 4N			Aneuploidy			9p LOH			17p LOH
		n	%^a	n	%^a	n	%^a	n	%^a	n	%^a
Total	429	14.9	385	9.6	385	10.4	283	55.1	281	19.6
Age (yrs)
30–44	34	8.8	31	6.5	31	6.5	22	63.6	21	23.8
45–54	103	9.7	90	6.7	90	5.6	63	55.6	63	12.7
55–64	103	12.6	90	7.8	90	8.9	61	60.7	60	18.3
65–74	119	19.3	110	13.6	110	13.6	86	55.8	86	22.1
≥75	70	21.4	64	10.9	64	15.6	51	43.1	51	23.5
Gender
Male	334	15.3	302	10.3	302	10.9	220	56.8	219	18.3
Female	95	13.7	83	7.2	83	8.4	63	49.2	62	24.2
Education
<High school	32	25.0	27	11.1	27	22.2	24	50.0	24	37.5
High school graduate	118	19.5	107	9.3	107	15.9	76	55.3	74	20.3
Some college	110	10.9	98	7.1	98	8.2	72	61.1	72	20.8
College graduate	168	12.5	152	11.2	152	5.9	110	52.7	110	14.5
BMI (kg/m²)
<25.0	65	21.5	54	11.1	54	11.1	45	48.9	45	20.0
25.0–27.4	85	12.9	82	7.3	82	12.2	61	49.2	60	26.7
27.5–29.9	104	15.4	97	13.4	97	12.4	79	62.0	78	16.7
≥30.0	166	13.3	143	8.4	143	7.7	93	57.0	93	17.2
Waist:hip ratio
Quartile 1	107	12.1	95	5.3	95	5.3	71	49.3	72	18.1
Quartile 2	107	12.1	95	8.4	95	7.4	77	48.1	76	14.5
Quartile 3	107	15.9	92	10.9	92	12.0	64	57.8	63	17.5
Quartile 4	106	18.9	101	13.9	101	16.8	70	67.1	69	29.0
Cigarette use^b
Never	147	10.9	131	7.6	131	9.2	97	54.6	97	18.6
Tertile 1	95	17.9	89	10.1	89	11.2	59	59.3	57	19.3
Tertile 2	96	16.7	84	11.9	84	4.8	61	63.9	61	21.3
Tertile 3	91	16.5	81	9.9	81	17.3	66	43.9	66	19.7
NSAID use
Never	176	17.0	157	10.2	157	12.7	119	53.8	117	26.5
Former	59	10.2	54	11.1	54	3.7	41	53.7	41	22.0
Current	193	14.5	173	8.7	173	10.4	122	56.6	122	12.3

^a Percentage with abnormality.
^b Classified into tertiles of pack-years among ever-smokers.