Table 1

P gene variants and eye color

Arg305TrpArg419GlnCombined variants
Arg/ArgArg/Trp or Trp/TrpArg/ArgArg/Gln or Gln/GlnArg onlyAny Trp or Gln
Blue/gray221 (90.2%)24 (9.8%)221 (89.1%)27 (10.9%)185 (78.7%)50 (21.3%)
Green/hazel142 (88.2%)19 (11.8%)121 (72.9%)45 (27.1%)101 (63.5%)58 (36.5%)
Brown/black154 (78.6%)42 (21.4%)166 (83.8%)32 (16.2%)122 (64.2%)68 (35.8%)
χ2 (df = 2)13.13 (P < 0.001)18.69 (P < 0.001)14.68 (P < 0.001)
ORa1.12 (0.59–2.15)3.00 (1.76–5.11)2.02 (1.28–3.18)
ORb2.48 (1.43–4.30)1.65 (0.85–2.88)2.08 (1.34–3.23)
ORc1.78 (1.07–2.96)2.45 (1.39–3.62)2.05 (1.39–3.01)
  • a OR comparison of blue/gray versus green/hazel adjusted for presence/absence of MM and presence/absence of DN.

  • b OR comparison of blue/gray versus brown/black adjusted for presence/absence of MM and presence/absence of DN.

  • c OR comparison of blue/gray versus green/hazel/brown/black adjusted for presence/absence of MM and presence/absence of DN.