Table 6

Interaction between IGF-II and IGF-I/IGFBP-3 in relation to breast cancer

VariableLow IGF-IIHigh IGF-II
ORa95% CIORa95% CI
IGF-I Low1.001.00
IGF-I Medium1.890.87–4.091.160.52–2.56
IGF-I High4.051.66–9.881.850.80–4.23
Test for trendP = 0.002P = 0.125
IGFBP-3 Low1.001.00
IGFBP-3 Med1.000.44–2.302.341.10–4.96
IGFBP-3 High2.370.91–6.184.321.71–10.93
Test for trendP = 0.098P = 0.002
  • a Adjusted for BMI, age at menarche, age at first live birth, total energy intake, WHR, history of fibroadenoma, and family history of breast cancer.