Table 5

Joint effect of IGFs and IGFBP-3 with BMI, WHR, and total calorie intake on breast cancer risk

Variable<Median≥Median
NumberORNumberOR
Case/control(95% CI)Case/control(95% CI)
BMI (median = 22.5)
IGF-I (ng/ml)
 <12748/731.00 (reference)62/771.11 (0.65–1.88)
 ≥12778/781.71 (1.02–2.88)110/722.44 (1.50–3.97)
IGF-II (ng/ml)
 <85665/731.00 (reference)84/771.24 (0.78–1.98)
 ≥85661/780.90 (0.47–1.71)88/721.42 (0.74–2.72)
IGFBP-3 (ng/ml)
 <401953/841.00 (reference)59/661.48 (0.89–2.47)
 ≥401973/671.97 (1.17–3.33)113/832.48 (1.51–4.07)
WHR (median = 0.7979)
IGF-I (ng/ml)
 <12740/751.00 (reference)70/751.82 (1.06–3.13)
 ≥12786/732.51 (1.47–4.26)102/773.10 (1.78–5.39)
IGF-II (ng/ml)
 <85673/861.00 (reference)76/641.54 (0.93–2.56)
 ≥85653/621.04 (0.54–2.00)96/881.38 (0.73–2.59)
IGFBP-3 (ng/ml)
 <401951/751.00 (reference)61/751.25 (0.75–2.09)
 ≥401975/731.62 (0.97–2.72)111/772.56 (1.52–4.32)
Total calorie intake (median = 2234)
IGF-I (ng/ml)
 <12758/861.00 (reference)52/631.18 (0.71–1.96)
 ≥127101/842.11 (1.28–3.48)88/672.18 (1.33–3.56)
IGF-II (ng/ml)
 <85675/811.00 (reference)74/691.18 (0.74–1.89)
 ≥85684/890.99 (0.53–1.85)66/611.16 (0.62–2.16)
IGFBP-3 (ng/ml)
 <401957/941.00 (reference)55/561.61 (0.96–2.71)
 ≥4019102/762.57 (1.56–4.23)85/742.06 (1.28–3.32)