Table 4

Associations of breast cancer risk with IGF-I, IGF-II, and IGFBP-3 in pre- and postmenopausal women

Variable	Number	Unadjusted			Number	Adjusted^a			Adjusted^b
Variable		Case/control	OR	95% CI	Case/control	OR	95% CI	OR	95% CI
Premenopausal women
IGF-I by tertile (ng/ml)
≤125.8	33/56	1.00		32/56	1.00		1.00
125.9–170.0	60/58	1.78	0.98–3.22	55/56	1.65	0.85–3.21	1.46	0.70–3.03
>170.0	78/56	2.41	1.35–4.29	74/55	2.29	1.20–4.37	1.92	0.88–4.20
Trend test		P = 0.003			P = 0.012		P = 0.236
IGF-II by tertile (ng/ml)
<718.7	52/56	1.00		50/54	1.00
718.8–936.5	53/58	1.32	0.61–2.89	50/58	1.17	0.50–2.71
>936.5	66/56	1.96	0.74–5.21	61/55	1.50	0.51–4.44
Trend test		P = 0.154			P = 0.439
IGFBP-3 by tertile (ng/ml)
≤3593	36/56	1.00		35/56	1.00		1.00
3594–4258	52/57	1.54	0.86–2.75	48/56	1.35	0.72–2.54	0.98	0.47–2.06
>4258	83/57	3.43	1.72–6.87	78/55	3.71	1.67–8.26	2.69	1.12–6.47
Trend test		P < 0.001			P = 0.002		P = 0.022
Postmenopausal women
IGF-I by tertile (ng/ml)
≤94.47	39/43	1.00		38/43	1.00		1.00
94.5–121.7	32/44	0.82	0.41–1.67	28/42	0.66	0.27–1.59	0.57	0.22–1.43
>121.7	57/43	1.52	0.80–2.88	56/41	1.97	0.93–4.19	1.56	0.68–3.57
Trend test		P = 0.155			P = 0.042		P = 0.166
IGF-II by tertile (ng/ml)
≤703.4	39/43	1.00		38/41	1.00
703.5–962.2	41/43	1.08	0.59–1.99	39/43	1.08	0.53–2.18
>962.2 ng/ml	48/44	2.13	0.72–6.33	45/42	2.17	0.60–7.90
Trend test		P = 0.281			P = 0.367
IGFBP-3 by tertile (ng/ml)
≤3779	26/43	1.00		25/40	1.00		1.00
3780–4863	47/43	1.65	0.88–3.07	44/42	1.52	0.75–3.10	1.40	0.65–2.98
>4863	55/44	2.37	1.08–5.18	53/44	2.60	1.03–6.56	2.11	0.76–5.87
Trend test		P = 0.027			P = 0.044		P = 0.178

^a Adjusted for BMI, age at menarche, age at first live birth, total energy intake, WHR, history of fibroadenoma, and family history of breast cancer.
^b Adjusted for BMI, age at menarche, age at first live birth, total energy intake, WHR, history of fibroadenoma, family history of breast cancer, and either IGFBP-3 or IGF-I.