Table 3

Relationship between VAT and insulin and the IGF-1 axis

Q1aQ2Q3Q4Trend test P
Men
 VAT (cm3)<135.8135.8–187.5187.6–254.4>254.4
 IGF-1 (>127)36303435
 IGF-1 (≤127)30373332
 OR unadj (95% CI)1.000.68 (0.34–1.34)0.86 (0.43–1.70)0.91 (0.46–1.80)0.977
 OR age-adj (95% CI)1.000.79 (0.38–1.65)1.07 (0.51–2.26)1.06 (0.52–2.16)0.595
 IGFBP-3 (>3066.5)33293339
 IGFBP-3 (≤3066.5)33383428
 OR unadj (95% CI)1.000.76 (0.39–1.51)0.97 (0.49–1.92)1.39 (0.70–2.76)0.262
 OR age-adj (95% CI)1.000.83 (0.41–1.68)1.15 (0.54–2.44)1.11 (0.53–2.33)0.157
 Ratio (>0.15753)33323039
 Ratio (≤0.15753)33353728
 OR unadj (95% CI)1.000.91 (0.46–1.80)0.81 (0.41–1.60)1.39 (0.70–2.76)0.428
 OR age-adj (95% CI)1.000.91 (0.44–1.88)0.92 (0.44–1.95)1.95 (0.88–4.30)0.210
 Insulin (>14.6)13273658
 Insulin (≤14.6)5340319
 OR unadj (95% CI)1.002.75 (1.26–6.00)4.73 (2.18–10.3)26.3 (10.4–66.5)<0.0001
 OR age-adj (95% CI)1.002.88 (1.23–6.73)5.87 (2.44–14.1)48.9 (14.4–166.0)<0.0001
Women
 VAT (cm3)<109.4109.4–155.3155.4–206.1>206.1
 IGF-1 (>104)18281921
 IGF-1 (≤104)23132221
 OR unadj (95% CI)1.002.75 (1.12–6.78)1.10 (0.46–2.64)1.28 (0.54–3.03)0.914
 OR age-adj (95% CI)1.002.82 (1.08–7.34)1.00 (0.38–2.60)1.30 (0.52–3.23)0.865
 IGFBP-3 (>3378.0)18202619
 IGFBP-3 (≤3378.0)23211523
 OR unadj (95% CI)1.001.22 (0.51–2.90)2.22 (0.91–5.37)1.06 (0.44–2.51)0.604
 OR age-adj (95% CI)1.001.27 (0.51–3.16)2.21 (0.84–5.79)1.21 (0.48–3.02)0.506
 Ratio (>0.11807)17231824
 Ratio (≤0.11807)24182318
 OR unadj (95% CI)1.001.80 (0.75–4.33)1.10 (0.46–2.65)1.88 (0.79–4.50)0.315
 OR age-adj (95% CI)1.001.90 (0.75–4.83)1.30 (0.46–3.72)1.92 (0.76–4.88)0.319
 Insulin (>13.7)7172435
 Insulin (≤13.7)3424177
 OR unadj (95% CI)1.003.44 (1.24–9.58)6.86 (2.46–19.1)24.3 (7.70–76.6)<0.0001
 OR age-adj (95% CI)1.002.01 (0.64–6.38)3.96 (1.36–11.6)30.7 (7.92–118.8)<0.0001
  • a Q, quartile; OR, odds ratio; unadj, unadjusted; age-adj, adjusted for age.