Table 1

Age, study site, and gender-adjusted ORs for variables from four colonoscopy-based studies

Advanced adenoma cases (n = 119)Nonadvanced adenoma cases (n = 441)Polyp-free controls (n = 1866)Advanced cases relative to polyp- free controls OR (95% CI)Nonadvanced cases relative to polyp-free controls OR (95% CI)Advanced cases relative to nonadvanced cases OR (95% CI)
Education
 < High school25723471.01.0
 High school27874001.1 (0.6–2.0)1.2 (0.8–1.8)0.9 (0.5–1.7)
 Some college23924830.7 (0.4–1.4)1.0 (0.7–1.5)0.7 (0.4–1.4)
 College graduate441896280.7 (0.4–1.3)1.1 (0.8–1.6)0.7 (0.4–1.2)
Race
 White10239015721.01.0
 Black13402291.0 (0.5–1.9)0.8 (0.5–1.2)1.3 (0.6–2.6)
 Other49640.8 (0.3–2.3)0.5 (0.2–1.9)1.8 (0.5–6.0)
Smoking status
 Never431688441.01.0
 Former551987281.2 (0.8–1.8)1.1 (0.8–1.4)1.1 (0.7–1.7)
 Current20742911.6 (0.9–2.8)1.4 (1.0–2.0)1.1 (0.6–2.0)
Family historya
 No first degree9833113061.01.01.0
 First degree15741871.0 (0.6–1.9)1.5 (1.1–2.1)0.7 (0.4–1.3)
Body mass index
 First quartile (low)28944611.01.0
 Second quartile291354541.4 (0.8–2.4)1.8 (1.3–2.5)0.8 (0.4–1.4)
 Third quartile291094581.5 (0.8–2.5)1.5 (1.1–2.1)0.9 (0.5–1.7)
 Fourth quartile (high)31924512.0 (1.2–3.6)1.6 (1.2–2.3)1.2 (0.7–2.3)
Alcohol use
 Nondrinker5620010751.01.0
 <4 drinks per week13522490.9 (0.5–1.7)1.0 (0.7–1.4)0.9 (0.5–1.8)
 4–< 9 drinks per week15742450.9 (0.5–1.7)1.2 (0.9–1.7)0.7 (0.4–1.4)
 ≥9 drinks per week351152971.3 (0.8–2.1)1.2 (0.9–1.6)1.1 (0.7–1.9)
Daily caloric intake
 First quartile (low)371464521.01.0
 Second quartile31924550.9 (0.6–1.6)0.7 (0.5–1.0)1.3 (0.8–2.3)
 Third quartile19894510.7 (0.4–1.2)0.8 (0.6–1.1)0.9 (0.5–1.6)
 Fourth quartile (high)24944540.9 (0.5–1.6)0.9 (0.6–1.2)1.1 (0.6–1.9)
Dietary fiber
 First quartile (low)331274541.01.0
 Second quartile281124470.9 (0.5–1.5)0.9 (0.7–1.2)1.0 (0.5–1.7)
 Third quartile281124580.9 (0.5–1.5)0.9 (0.7–1.3)1.0 (0.5–1.7)
 Fourth quartile (high)22724510.8 (0.4–1.5)0.7 (0.5–1.0)1.2 (0.6–2.3)
Dietary fat
 First quartile (low)371284521.01.0
 Second quartile19914540.5 (0.3–0.9)0.7 (0.5–1.0)0.7 (0.4–1.3)
 Third quartile30824490.9 (0.6–1.6)0.7 (0.5–1.0)1.3 (0.7–2.3)
 Fourth quartile (high)251224540.8 (0.5–1.4)1.1 (0.8–1.5)0.7 (0.4–1.3)
Aspirin
 No16805601.01.0
 Yes11372831.1 (0.5–2.4)0.7 (0.4–1.0)1.6 (0.7–4.0)
Other nonsteroidal anti-inflammatory drugs
 No24976181.01.0
 Yes3121390.6 (0.2–2.0)0.6 (0.3–1.1)1.0 (0.3–3.8)
Leisure Activity
 Less than 2 h/week9533614051.01.0
 More than 2 h/week16733160.7 (0.4–1.2)0.8 (0.6–1.1)0.8 (0.4–1.5)
Age at menarcheb
 <127251781.01.0
 12 years7292510.7 (0.2–1.9)0.8 (0.4–1.4)0.8 (0.3–2.8)
 13 years14483010.9 (0.4–2.4)0.9 (0.5–1.6)1.0 (0.4–2.8)
 >13 years18582531.4 (0.6–3.5)1.3 (0.8–2.2)1.0 (0.4–2.9)
Parityb
 Nulliparous11401991.01.0
 19141281.5 (0.6–4.0)0.6 (0.3–1.3)2.4 (0.8–6.9)
 211452800.8 (0.3–2.0)0.9 (0.5–1.5)0.9 (0.4–2.3)
 35321900.8 (0.3–2.3)1.3 (0.7–2.2)0.6 (0.2–1.9)
 4+13392501.8 (0.7–4.3)1.3 (0.8–2.3)1.3 (0.5–3.5)
Use of oral contraceptives (OCs)b
 Never371275431.01.0
 Ever8354480.8 (0.3–1.9)0.9 (0.6–1.5)0.9 (0.3–2.3)
Use of hormone replacement therapy (HRT)b
 Never371125751.01.0
 Ever8434010.4 (0.2–1.0)0.8 (0.5–1.2)0.5 (0.2–1.3)
  • a Family history analyses restricted to subjects whose indication for colonoscopy was not because of previous family history.

  • b Women only.