Table 4

Associationsa between dietary and lifestyle factors and specific types of p53 mutations compared with controlsb

OR (referent)OR (95% CI)OR (95% CI)P trend
Diet
 WesternLowIntermediateHigh
  Transition1.001.30 (1.00–1.71)1.94 (1.43–2.65)<0.01
  Transversion1.001.50 (0.85–2.65)2.13 (1.13–4.03)<0.01
  Missense1.001.31 (1.01–1.71)1.92 (1.42–2.60)<0.01
  Frameshift1.001.31 (0.67–2.56)1.17 (0.50–2.77)0.86
  Stop codon1.001.31 (0.63–2.74)2.50 (1.13–5.54)0.01
  CpG1.001.28 (0.93–1.76)1.86 (1.29–2.68)<0.01
 GI/Sugar
  Transition1.001.43 (1.06–1.93)1.74 (1.25–2.43)<0.01
  Transversion1.000.97 (0.57–1.65)1.21 (0.67–2.20)0.23
  Missense1.001.33 (1.00–1.77)1.69 (1.23–2.33)<0.01
  Frameshift1.000.91 (0.47–1.74)0.53 (0.22–1.27)0.20
  Stop codon1.001.23 (0.60–2.55)1.25 (0.55–2.87)0.96
  CpG1.001.37 (0.96–1.95)1.54 (1.04–2.28)0.05
 Red meat/fast food/trans-fatty acid diet
  Transition1.001.10 (0.85–1.42)1.83 (1.37–2.45)<0.01
  Transversion1.002.28 (1.23–4.25)2.60 (1.31–5.16)0.01
  Missense1.001.26 (0.98–1.63)1.92 (1.14–2.56)<0.01
  Frameshift1.001.16 (0.61–2.20)1.29 (0.59–2.82)0.54
  Stop codon1.000.97 (0.51–1.86)1.60 (0.78–3.28)0.10
  CpG1.000.92 (0.68–1.25)1.57 (1.12–2.22)<0.01
Lifestyle
 Physical activityHighIntermediateLow
  Transition1.001.10 (0.88–1.38)1.39 (1.08–1.80)<0.01
  Transversion1.001.80 (1.13–2.87)2.48 (1.47–4.19)<0.01
  Missense1.001.22 (0.98–1.52)1.59 (1.24–2.04)<0.01
  Frameshift1.000.99 (0.55–1.78)1.18 (0.61–2.30)0.62
  Stop codon1.001.26 (0.72–2.23)1.48 (0.76–2.89)0.07
  CpG1.001.19 (0.91–1.55)1.51 (1.11–2.05)<0.01
 BMI [wt (kg)/ht (m)2]<2525–29>29
  Transition1.001.05 (0.83–1.32)1.43 (1.13–1.80)<0.01
  Transversion1.000.94 (0.58–1.54)1.93 (1.24–3.01)<0.01
  Missense1.000.98 (0.78–1.23)1.52 (1.21–1.90)<0.01
  Frameshift1.000.92 (0.50–1.69)1.24 (0.68–2.27)0.12
  Stop codon1.001.60 (0.90–2.86)1.33 (0.70–2.52)0.16
  CpG1.001.04 (0.79–1.37)1.37 (1.04–1.81)<0.01
 Smoking (cigarettes/day)None<20≥20
  Transition1.000.95 (0.73–1.23)1.27 (1.02–1.58)<0.01
  Transversion1.001.32 (0.80–2.19)1.60 (1.04–2.47)<0.01
  Missense1.000.95 (0.74–1.23)1.31 (1.06–1.62)<0.01
  Frameshift1.001.49 (0.81–2.74)0.99 (0.54–1.84)0.70
  Stop codon1.001.40 (0.76–2.60)1.24 (0.70–2.21)0.14
  CpG1.000.85 (0.62–1.17)1.17 (0.90–1.51)0.14
 Aspirin/NSAID (regular use)YesNo
  Transition1.001.41 (1.16–1.71)
  Transversion1.001.27 (0.87–1.85)
  Missense1.001.37 (1.13–1.65)
  Frameshift1.001.84 (1.09–3.11)
  Stop codon1.002.12 (1.25–3.61)
  CpG1.001.41 (1.12–1.78)
  • a Adjusted for age and gender.

  • b For associations between Wt and controls, see Table 3<$REFLINK> .