Table 2

Effects of 3 months of treatment with letrozole on mean serum hormone levels

Geometric means were used for E2 and IGF-I, otherwise arithmetic means were used. E2 values below the detection limit (3 pmol/liter) were recorded as 2.9 pmol/liter. P (w) indicates within-group, Wilcoxon-rank-derived Ps versus pretreatment.

AnalyteTimeMean (95% CI) (n)P (w)
E2 (pmol/liter)Pretreatment17.1 (13.2–22.3)
(29)
12 wks3.4 (2.9–4.0)<0.001
(29)
SHBG (nmol/liter)Pretreatment49.6 (42.2–57.0)
(27)
12 wks50.9 (42.8–58.8)0.65
(27)
IGF-I (nmol/liter)Pretreatment21.5 (17.5–26.8)
(27)
12 wks22.6 (18.7–27.2)0.23
(27)