Table 3

Associationsa between diet and lifestyle factors in cases with and without p53 mutations compared with controls

OR (referent)OR (95% CI)OR (95% CI)P trend
Diet
 WesternLowIntermediateHigh
n cases M/Wt/controls97/123/482402/470/1461187/179/467
 Mutation1.001.37 (1.07–1.75)2.03 (1.53–2.69)<0.01
 Wt1.001.28 (1.02–1.60)1.57 (1.20–2.06)0.02
 GI/SugarLowIntermediateHigh
n cases M/Wt/controls86/124/382420/477/1490180/171/538
 Mutation1.001.25 (0.96–1.61)1.48 (1.11–1.98)<0.01
 Wt1.000.99 (0.79–1.24)0.98 (0.75–1.28)0.53
 Red meat/fast food/trans-fatty acidLowIntermediateHigh
n cases M/Wt/controls113/147/553366/434/1356207/191/521
 Mutation1.001.28 (1.01–1.62)1.92 (1.47–2.50)<0.01
 Wt1.001.18 (0.95–1.46)1.39 (1.08–1.80)0.01
Lifestyle
Physical activityHighIntermediateLow
n cases M/Wt/controls220/229/890277/329/985189/214/535
 Mutation1.001.16 (0.95–1.42)1.54 (1.22–1.93)<0.01
 Wt1.001.31 (1.08–1.60)1.59 (1.27–1.99)<0.01
 BMI [wt (kg)/ht (m)2]<2525–29>29
n cases M/Wt/controls235/252/965217/281/831234/239/624
 Mutation1.000.99 (0.80–1.24)1.43 (1.16–1.76)<0.01
 Wt1.001.24 (1.00–1.53)1.49 (1.22–1.83)<0.01
 Smoking (cigarettes/day)None<20≥20
n cases M/Wt/controls281/337/1121135/142/498266/290/786
 Mutation1.001.08 (0.86–1.36)1.33 (1.09–1.62)<0.01
 Wt1.000.95 (0.76–1.19)1.25 (1.04–1.51)<0.01
 Aspirin/NSAID (regular use)YesNo
n cases M/Wt/controls266/291/1150420/481/1260
 Mutation1.001.43 (1.20–1.71)
 Wt1.001.53 (1.29–1.81)
  • a Adjusted for age and gender; comparisons made to population-based controls. M, mutation.