Table 1

Description of p53 mutations in the population

Total n (%)Men n (%)Women n (%)<65 n (%)>65 n (%)
p53 Wt772 (52.9)409 (51.6)363 (54.6)321 (51.5)451 (54.0)
p53 mutations686 (47.1)a384 (48.4)302 (45.4)302 (48.5)384 (46.0)
 Transition528 (77.0)287 (74.7)241 (79.8)240 (79.5)288 (75.0)
 Transversion117 (17.1)71 (18.5)46 (15.2)55 (18.2)62 (16.1)
 Missense562 (81.9)311 (81.0)251 (83.1)250 (82.8)312 (81.3)
 Frameshift65 (9.5)36 (9.4)29 (9.6)22 (7.3)43 (11.2)
 Stop68 (9.9)38 (9.9)30 (9.9)36 (11.9)32 (8.3)
 In-frame insertion/deletion20 (2.9)15 (3.9)5 (1.7)5 (1.7)15 (3.9)
 Splice site18 (2.6)10 (2.6)8 (2.6)10 (3.3)8 (2.1)
 CpG dinucleotides355 (51.7)201 (52.3)154 (51.0)163 (54.0)192 (50.0)
 R27380 (11.7)44 (11.5)36 (11.9)42 (13.9)38 (9.9)
 R24879 (11.5)39 (10.2)40 (13.2)30 (9.9)49 (12.8)
 L2 loop110 (16.0)66 (17.2)44 (14.6)54 (17.9)56 (14.6)
 L3 loop143 (20.8)74 (19.3)69 (22.8)63 (20.9)80 (20.8)
 LSH189 (27.6)102 (26.6)87 (28.8)86 (28.5)103 (26.8)
 β Sandwich64 (9.3)40 (10.4)24 (7.9)23 (7.6)41 (10.7)
 Contact165 (24.1)86 (22.4)79 (26.2)73 (24.2)92 (24.0)
 Structure397 (57.9)225 (58.6)172 (57.0)177 (58.6)220 (57.3)
 Denaturing131 (19.1)80 (20.8)51 (16.9)62 (20.5)69 (18.0)
  • a The number of individuals with a p53 mutation was 686. Because some people had multiple mutations, the total number of mutations does not add up to 686. Percentages are based on the percentage of people with the mutation rather than the percentage of all mutations.