Table 1

Association between CYP1B1 genotype and breast cancer risk

CYP1B1 genotypeCases (n = 453)Controls (n = 453)aORs (95% CI)Adjusted OR (95% CI)
m1 (codon 432)n (%)n (%)
 Val/Val92 (20)91 (20)1.00b1.00c
 Val/Leu232 (51)200 (44)1.19 (0.83–1.69)1.13 (0.77–1.67)
 Leu/Leu129 (28)162 (36)0.80 (0.56–1.15)0.92 (0.62–1.36)
 Val/Leu+ Leu/Leu361 (80)362 (80)1.00 (0.72–1.36)1.00 (0.72–1.45)
m2 (codon 453)
 Asn/Asn318 (70)299 (66)1.00b1.00c
 Asn/Ser126 (28)137 (30)0.83 (0.62–1.11)0.88 (0.64–1.20)
 Ser/Ser9 (2)17 (4)0.50 (0.21–1.18)0.57 (0.23–1.42)
 Asn/Ser + Ser/Ser135 (30)154 (34)0.80 (0.60–1.06)0.85 (0.62–1.15)
  • a Three controls were excluded for conditional analysis.

  • b Conditional logistic regression adjusted for the matching variables: age, menopausal status, postmenopausal hormone use, date at blood draw, time at blood draw, and fasting status.

  • c Conditional logistic regression adjusted for matching variables and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.