Table 2

Risk of breast cancer associated with the BRCA2 N362H genotype according to different models of inheritancea

Including carriers of BRCA1 or BRCA2 deleterious mutationsExcluding carriers of BRCA1 or BRCA2 deleterious mutations
Crude OR (95% CI)PAdjusted OR (95% CI)PCrude OR (95% CI)PAdjusted OR (95% CI)P
Codominant inheritance
NNReferenceReferenceReferenceReference
NH1.03 (0.86–1.24)0.71.02 (0.84–1.24)0.81.01 (0.84–1.22)0.91.03 (0.85–1.24)0.8
HH1.49 (1.05–2.11)0.021.43 (1.00–2.05)0.051.46 (1.03–2.07)0.041.40 (0.98–2.01)0.07
Multiplicative risk per H allele1.13 (0.99–1.30)0.071.12 (0.97–1.29)0.11.12 (0.98–1.29)0.11.11 (0.96–1.28)0.2
Dominant inheritance
NNReferenceReferenceReferenceReference
NH/HH1.10 (0.92–1.31)0.31.08 (0.90–1.30)0.41.08 (0.91–1.29)0.41.07 (0.89–1.28)0.5
Recessive inheritance
NN/NHReferenceReferenceReferenceReference
HH1.47 (1.05–2.07)0.021.42 (1.00–2.02)0.051.46 (1.04–2.06)0.031.42 (1.00–2.02)0.05
  • a Adjusted ORs were adjusted for age, country of birth, state, education, marital status, number of live births, height, weight, age at menarche, oral contraceptive use, and for reported family history of breast cancer (first- or second-degree).