Table 1

Association between spontaneous regression of CIN in 12 months and CMI responses to HPV 16 E6 and E7 peptides

HPV 16 peptidesCMI responses to specific peptidesaNo. with regression/total (%)bAdjusted OR for regression (95% CI)P
E7
 105
Negative38/92 (41.3)1
Positive28/41 (68.3)2.87 (1.29–6.40)0.010
 Any E7 peptide(s)
Negative18/41 (43.9)1
Positive50/95 (52.6)1.53 (0.71–3.30)0.279
E6
 370
Negative49/103 (47.6)1
Positive18/30 (60.0)1.71 (0.72–4.07)0.227
 373/377
Negative35/77 (45.5)1
Positive31/55 (56.4)1.82 (0.87–3.82)0.112
 Any E6 peptide(s)
Negative3/9 (33.3)1
Positive65/127 (51.2)2.70 (0.62–11.79)0.186
  • a ORs were adjusted for age and education.

  • b The numbers presented here do not include all of the subjects enrolled (136); not all of them could be tested with all of the individual peptides separately because, occasionally, insufficient PBMCs were obtained.