Table 3

Age-adjusted relative risk of CRC mortality associated with potential risk factors in the CHA Detection Project in Industry

Risk factorMenWomen
No. of deathsTotal person-yearsAge-adjusted RR95% CINo. of deathsTotal person-yearsAge-adjusted RR95% CI
PLG, mg/dl
 ≤1956221,0851.0031185,3741.00
 120–15971163,6491.100.77–1.5756118,3521.741.11–2.72
 160–1993372,9520.860.55–1.332350,2121.320.76–2.30
 ≥2003133,3071.510.96–2.401621,9941.861.00–3.45
P for trend0.220.10
Quartiles of BMI,a kg/m2
 Q133125,4201.001995,1631.00
 Q241124,0381.070.68–1.692695,5620.920.51–1.67
 Q356123,0461.270.82–1.964193,8681.110.64–1.93
 Q461118,4891.400.91–2.144091,3390.940.54–1.65
P for trend0.080.86
Quartiles of SBP,b mm Hg
 Q135126,9591.001483,4481.00
 Q237120,7751.000.63–1.582088,8731.060.53–2.09
 Q339115,4700.980.62–1.5546128,6821.180.64–2.17
 Q480127,5721.360.91–2.054674,6101.240.66–2.31
P for trend0.070.47
Quartiles of heart rate,c beats/min
 Q141104,5291.003078,8701.00
 Q244105,3841.040.68–1.603390,8111.070.65–1.75
 Q333105,2280.840.53–1.323282,9441.330.80–2.19
 Q451102,4881.320.88–2.002285,1001.030.59–1.79
P for trend0.230.74
Quartiles of uric acid,d mg/dl
 Q13586,5881.001679,5601.00
 Q23073,0281.040.64–1.702370,5691.260.66–2.39
 Q33087,5530.870.53–1.412566,8171.200.64–2.26
 Q43176,3251.000.62–1.623973,2851.310.72–2.38
P for trend0.860.44
Quartiles for height,e m
 Q155126,9141.004287,2871.00
 Q245132,8580.920.62–1.3736109,3100.840.54–1.32
 Q351126,8861.340.91–1.9730104,0980.860.54–1.38
 Q440104,3351.500.99–2.281875,2380.920.52–1.61
P for trend0.030.72
Education
 Less than high school4688,2231.003376,2331.00
 High school graduate75150,9001.370.94–1.9969189,2441.500.98–2.29
 Some college or trade2595,2760.800.49–1.302065,3791.470.84–2.59
 College graduate45156,5940.930.61–1.41445,0770.440.16–1.26
P for trend0.310.75
Smoking
 Never smoked53134,5771.0062169,3721.00
 Past smoker68147,0990.970.68–1.391560,1050.830.47–1.46
 Smoke 1–20 cigsf/day40139,5310.910.60–1.3841119,9641.390.93–2.08
 Smoke >20 cigs/day3069,7871.360.86–2.13826,4911.400.66–2.94
Race
 White/other182459,3021.00117324,3211.00
 African-American931,6910.950.49–1.86951,6111.330.66–2.70
Insulin resistance clustering: in the upper quartile of the distribution on PLG, SBP, BMI, or heart rate
 0 of 4 components43167,7801.0029136,0831.00
 1 of 4 components47136,3211.000.66–1.5240116,4371.110.68–1.80
 2 of 4 components4875,1511.500.99–2.293057,7381.210.72–2.04
 ≥3 of 4 components3138,2131.671.04–2.681827,3101.250.68–2.29
  • a Cutpoints for quartiles of BMI (kg/m2) for men were ≤24.13, 24.14–26.29, 26.30–28.63, and ≥28.65; for women, ≤20.97, 20.98–23.23, 23.24–26.17, and ≥26.22.

  • b Cutpoints for SBP (mm HG) for men were ≤128, 130–138, 140–148, and ≥150; for women, ≤118, 120–129, 130–140, and ≥142.

  • c Cutpoints for heart rate (beats/min) for men were ≤67, 68–74, 75–83, and ≥84; for women, ≤69, 70–76, 77–85, ≥86.

  • d Cutpoints for uric acid (mg/dl) for men were ≤5.3, 5.4–6.0, 6.1–6.9, ≥7.0; for women, ≤3.7, 3.8–4.3, 4.4–5.0, ≥5.1.

  • e Cutpoints for height (cm) for men were ≤170.2, 172.7–175.3, 177.7–180.3, and ≥182.9; for women, ≤157.5, 160.0–162.6, 165.1–167.6, and ≥170.2.

  • f cigs, cigarettes.