Table 4

ORs and 95% CIs for incidence of breast cancer associated with total unconjugated progesterone, estrone, estradiol, and estrone levels (ng/ml) in the third trimester of pregnancy

Category meanCases (n = 194)Controls (n = 374)ORa95% CIP for trendORb95% CIP for trend
Progesterone
 <124.25106.426371.0Referent1.0Referent
 124.25 to <197.11163.51062030.690.39–1.20.660.38–1.2
 197.11 to <269.97226.346970.630.34–1.20.570.30–1.1
 ≥269.97321.416370.560.26–1.20.490.22–1.1
0.160.08
Estrone
 <3.362.610381.0Referent1.0Referent
 3.36 to <11.037.01132192.00.94–4.11.80.87–3.9
 11.03 to <18.7014.745802.10.96–4.82.00.88–4.5
 ≥18.7025.926372.71.1–6.52.51.0–6.1
0.090.12
Estradiol
 <13.3911.019381.0Referent1.0Referent
 13.39 to <26.6619.91032001.00.56–1.91.00.55–1.9
 26.66 to <39.9231.657981.20.61–2.41.10.58–2.3
 ≥39.9249.415380.770.33–1.80.710.30–1.7
0.680.48
Estriol
 <7.396.011371.0Referent1.0Referent
 7.39 to <13.5210.6961721.90.91–3.91.90.91–4.0
 13.52 to <19.6515.9731281.80.88–3.91.90.88–3.9
 ≥19.6524.814371.20.49–3.11.30.50–3.2
0.840.90
  • a OR controlling for age at index pregnancy (n = 568).

  • b OR controlling for age at index pregnancy, number of previous full-term pregnancies, and age at first full-term pregnancy (n = 568).