Table 3

Associations between CYP17 genotype and prostate cancer stratified by selected characteristics among white subjects

CharacteristicGenotypePa
A1/A1A1/A2A2/A2
First-degree family history of prostate cancer
 No1.00b0.78 (0.59–1.03)0.69 (0.47–1.03)0.0005
 Yes1.36 (0.79–2.35)1.19 (0.57–2.50)19.2 (2.23–157.4)
BMI
 18–231.00c0.84 (0.49–1.43)0.46 (0.20–1.09)0.048
 24–260.78 (0.47–1.28)1.17 (0.59–2.33)2.35 (0.83–6.64)
 27–290.69 (0.40–1.20)1.01 (0.47–2.16)1.47 (0.47–4.59)
 ≥300.91 (0.48–1.73)0.51 (0.21–1.23)3.54 (0.99–12.6)
Physical activity, times per week
 None1.00c0.88 (0.45–1.72)1.14 (0.41–3.13)0.75
 ≤10.79 (0.42–1.46)0.73 (0.31–1.70)0.91 (0.27–3.12)
 2–30.86 (0.48–1.56)1.02 (0.45–2.28)0.83 (0.26–2.68)
 ≥40.94 (0.50–1.75)0.93 (0.40–2.17)0.49 (0.14–1.79)
Smoking habits
 Never1.00c0.81 (0.53–1.25)0.95 (0.53–1.71)0.51
 Former1.12 (0.73–1.72)1.04 (0.59–1.86)0.77 (0.35–1.72)
 Current1.23 (0.70–2.15)0.76 (0.35–1.67)1.52 (0.48–4.78)
Number alcohol drinks/week
 Nondrinker1.00c0.62 (0.26–1.49)0.54 (0.15–1.99)0.82
 ≤31.40 (0.64–3.07)1.19 (0.42–3.36)2.05 (0.46–9.11)
 4–131.35 (0.65–2.83)1.30 (0.50–3.41)1.34 (0.33–5.45)
 ≥141.36 (0.61–3.01)1.51 (0.54–4.22)2.40 (0.51–11.3)
  • a P for interaction of genotype with selected characteristic.

  • b ORs are adjusted for age; 95% CI are in parentheses.

  • c ORs are adjusted for age and family history of prostate cancer.