Table 3

Relationship of time since last live/still birth to tumor characteristicsa

Tumor characteristicTime since last live/still birthAge-adjusted ORb
Never had5+ yrs2–<5 yrs<2 yrsEver5+ yrs2–<5 yrs<2 yrs
AJCC stage
 I125 (41.3)259 (39.9)33 (28.5)25 (30.5)
 IIA91 (30.0)201 (31.0)36 (31.0)22 (26.8)1.2 (0.9–1.6)1.2 (0.8–1.6)1.5 (0.9–2.6)1.2 (0.6–2.2)
 IIB56 (18.5)123 (19.0)28 (24.1)18 (22.0)1.4 (0.9–2.0)1.3 (0.8–1.9)1.9 (1.0–3.4)1.5 (0.7–2.9)
 III+31 (10.2)66 (10.2)19 (16.4)17 (22.0)1.3 (0.8–2.1)1.0 (0.6–1.6)2.3 (1.2–4.6)2.8 (1.3–5.8)
Nodal status
 Negative199 (65.9)392 (59.7)59 (50.4)38 (46.9)
 Positive103 (34.1)265 (40.3)58 (49.6)43 (53.1)1.6 (1.2–2.1)1.4 (1.1–1.9)1.9 (1.2–2.9)2.1 (1.3–3.5)
Ploidy
 Diploid69 (37.7)156 (39.7)23 (33.8)14 (32.6)
 Aneuploid114 (62.3)237 (60.3)45 (66.2)29 (67.4)1.0 (0.7–1.4)0.9 (0.6–1.3)1.2 (0.7–2.1)1.3 (0.6–2.6)
Tumor size
 ≤2 cm164 (54.5)354 (54.9)51 (44.0)38 (46.3)
 >2–5 cm113 (37.5)250 (38.8)49 (42.2)33 (40.2)1.2 (0.9–1.6)1.2 (0.9–1.6)1.4 (0.9–2.2)1.2 (0.7–2.0)
 >5 cm24 (8.0)41 (6.4)16 (13.8)11 (13.4)1.1 (0.7–1.9)0.8 (0.5–1.4)2.1 (1.1–4.3)2.0 (0.9–4.4)
Histologic grade
 Low45 (19.1)127 (24.1)12 (12.4)3 (4.6)
 Intermed95 (40.3)193 (36.6)45 (46.4)21 (31.8)1.0 (0.6–1.5)0.8 (0.5–1.3)1.7 (0.8–3.6)3.1 (0.9–10.9)
 High96 (40.7)208 (39.4)40 (41.2)42 (63.6)1.2 (0.8–1.8)1.0 (0.6–1.5)1.5 (0.7–3.2)5.9 (1.7–20.1)
Mitoses
 Low91 (38.6)227 (43.0)42 (43.3)15 (22.7)
 Intermed77 (32.6)161 (30.5)27 (27.8)25 (37.9)0.9 (0.6–1.3)0.9 (0.6–1.3)0.8 (0.4–1.3)1.9 (0.9–3.9)
 High68 (28.8)140 (26.5)28 (28.9)26 (39.4)1.0 (0.7–1.5)0.9 (0.6–1.4)0.9 (0.5–1.6)2.2 (1.1–4.5)
S phase fraction
 Low90 (53.3)175 (50.1)28 (45.2)13 (32.5)
 High79 (46.8)174 (49.9)34 (54.8)27 (67.5)1.3 (0.9–1.9)1.2 (0.8–1.8)1.4 (0.8–2.5)2.3 (1.1–4.8)
Ki-67 ratio
 0–24%139 (65.9)278 (60.6)48 (57.1)33 (55.0)
 25–100%72 (34.1)181 (39.4)36 (42.9)27 (45.0)1.5 (1.1–2.1)1.5 (1.1–2.2)1.5 (0.9–2.5)1.5 (0.8–2.7)
ER
 Positive130 (61.0)290 (62.6)50 (59.5)30 (50.0)
 Negative83 (39.0)173 (37.4)34 (40.5)30 (50.0)1.1 (0.8–1.6)1.1 (0.8–1.5)1.1 (0.6–1.8)1.5 (0.8–2.7)
PR
 Positive138 (64.8)289 (62.6)48 (57.8)27 (45.0)
 Negative75 (35.2)173 (37.5)35 (42.2)33 (55.0)1.4 (1.0–1.9)1.3 (0.9–1.8)1.4 (0.8–2.3)2.2 (1.2–3.9)
c-erbB-2
 Negative116 (54.5)253 (54.5)40 (48.2)30 (50.0)
 Positive97 (45.5)211 (45.5)43 (51.8)30 (50.0)1.1 (0.8–1.5)1.0 (0.7–1.4)1.3 (0.8–2.1)1.2 (0.7–2.1)
P53
 Negative144 (67.3)286 (61.8)36 (42.9)26 (43.3)
 Positive70 (32.7)177 (38.2)48 (57.1)34 (56.7)1.7 (1.2–2.4)1.4 (1.0–2.0)2.8 (1.6–4.7)2.6 (1.5–4.7)
  • a Not all tests were completed on the tumors of all women.

  • b Adjusted for age and diagnosis year.