RR of colon cancer according to multivitamin supplement use in 1980 and family history of colorectal cancera,b
| Multivitamin use | No family history | Positive family history | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of cases | Person-years | Age-adjusted RR (95% CI) | Multivariate RR (95% CI) | No. of | Person-years | Age-adjusted RR (95% CI) | Multivariate RR(95% CI) | |||||||
| No | 298 | 820,189 | 1.0 | 1.0 | 85 | 90,041 | 2.30 (1.82–2.90) | 2.18 (1.71–2.78) | ||||||
| Yes | 130 | 420,485 | 0.84 (0.68–1.03) | 0.89 (0.72–1.10) | 22 | 47,320 | 1.13 (0.73–1.74) | 1.13 (0.73–1.75) | ||||||
a Multivariate RRs are adjusted for age (5-year categories), pack-years of smoking before age 30 years (0, 1–5, 6–10, 11–15, or >15 pack-years), body-mass index (in quintiles), regular vigorous exercise (≥1 day/week), regular aspirin use (≥2 times per week), screening endoscopy (yes or no), beef, pork, or lamb as a main dish (<1 per month, 1–3 per month, 1 per week, 2–4 per week, or ≥5 per week), alcohol consumption (abstinence, history of greatly reduced consumption, or <15, 15–30, or >30 g/day), and energy-adjusted levels of methionine (≤1.4, 1.5–1.8, 1.9–2.2, >2.3 g/day).
b P for interaction for the cross-product term of multivitamin supplement use in 1980 and family history of colorectal cancer = 0.04.