Table 6

E-cadherin protein expression in ACF and non-ACF cryptsa

Treatment groupACF cryptsNon-ACF crypts
AOM31 ± 22b89 ± 26
AOM+ UDCA65 ± 35c103 ± 43
AOM+ F6-D364 ± 38c109 ± 41
  • a E-cadherin expression in the indicated groups assessed by quantitative Western blotting as described in the “Materials and Methods” (n = 6 animals in each group, with 4 ACF and 4 non-ACF biopsies from each carcinogen-treated rat and 4 normal biopsies from each of the saline-treated control groups). E-cadherin expression did not differ among saline-treated unsupplemented rats and UDCA and F6-D3-supplemented rats. Data are expressed as % E-cadherin in normal crypts from saline-treated rats (means ± SD).

  • b P < 0.05, compared with control.

  • c P < 0.05, compared with ACF crypts in AOM-alone group.