Table 5

Association between aspirin and NSAIDs and incident breast cancer by extent of diseasea

In situ disease n = 130 cases n = 26,663 noncasesLocal disease n = 629 cases n = 26,663 noncasesRegional or distant disease n = 171 cases n = 26,663
Multivariate-adjusted RR95% CIMultivariate-adjusted RR95% CIMultivariate-adjusted RR95% CI
Aspirin use
 Nonuse1.001.001.00
 <1 per week0.570.35–0.940.900.72–1.121.100.72–1.67
 1 per week1.220.61–2.440.930.63–1.371.710.93–3.13
 2–5 per week0.520.28–0.950.850.65–1.090.970.59–1.58
 6+ per week0.520.30–0.900.800.63–1.030.500.29–0.88
P trend = 0.03P trend = 0.077P trend = 0.016
NSAID use
 Nonuse1.001.001.00
 <1 per week1.350.83–2.211.050.83–1.331.030.66–1.61
 1 per week0.520.27–1.010.580.18–1.84
 2–5 per week0.670.29–1.560.950.69–1.310.950.52–1.74
 6+ per week1.280.77–2.131.030.80–1.320.760.45–1.30
P trend = 0.77P trend = 0.90P trend = 0.34
  • a Adjusted for age (continuous), BMI (continuous), estrogen use (current or not current), family history of breast cancer (yes or no), benign breast disease (yes or no), multivitamin use (yes or no), mammography (yes or no), and waist:hip ratio (continuous). Aspirin analyses are adjusted for NSAIDs, and NSAID analyses are adjusted for aspirin use.