Table 3

SIRs, familial proportions (% of affected offspring with affected parent and sibling), and PAFs for parent and sibling history

Cancer siteICD-7/histologySIR95% CIOaProportion (%)PAF (%)
Small intestinal carcinoids152/086 5,197.51 b 489.9714,896.7321.081.08
Colorectal adenocarcinoma153–4/096 7.74 5.0910.93270.550.48
Lung162–3 4.04 1.058.9740.110.09
Breastc170 2.82 2.253.45840.650.42
Endometriumc172 24.61 8.8648.2560.400.39
Ovaryc175 27.31 9.8353.5360.270.26
Prostated177 8.74 5.1713.25181.120.99
Bladder181 12.50 3.2527.7540.160.14
Melanoma190 10.21 4.8617.51100.130.11
Nervous system193 14.93 6.3727.0680.100.09
Thyroid194 243.51 135.87382.34150.640.64
Endocrine195 52.60 18.93103.1260.190.19
  • a O, observed cases with affected parent and sibling.

  • b Bold type: 95% CI does not include 1.00.

  • c Families with ≥2 daughters.

  • d Families with ≥2 sons.