Table 7

ORs for colon cancer in relation to MTHFR codon 677 and 1298 genotypes and alcohol intake in African-American and white participants

African AmericansWhites
Cases/controlsORa (95% CI)Cases/controlsORa (95% CI)
MTHFR 677 genotype
 CC+ CTNeverb8 /262Reference172 /298Reference
 TTNeverb3 /41.0 (0.3–4.7)13 /241.0 (0.5–2.1)
 CC+ CTEverb51 /611.0 (0.7–1.6)110 /1900.9 (0.7–1.3)
 TTEverb0 /2ndc11 /270.7 (0.3–1.4)
 CCNeverb155 /215Reference86 /159Reference
 TT+ CTNeverb36 /511.0 (0.6–1.6)99 /1631.2 (0.5–1.9)
 CCEverb41 /491.0 (0.6–1.6)57 /1060.9 (0.6–1.4)
 TT+ CTEverb10 /141.0 (0.4–2.3)64 /1111.0 (0.7–1.5)
MTHFR 1298 genotype
 AA+ ACNeverb187 /256Reference176 /279Reference
 CCNeverb4 /100.6 (0.2–1.9)9 /420.3 (0.2–0.7)
 AA+ ACEverb46 /600.9 (0.6–1.5)111 /1940.8 (0.6–1.2)
 CCEverb4 /31.7 (0.4–8.1)d11 /260.6 (0.3–1.3)
 AANeverb128 /176Reference96 /142Reference
 CC+ ACNeverb63 /881.0 (0.7–1.5)89 /1790.7 (0.5–1.0)
 AAEverb27 /390.9 (0.5–1.5)59 /950.9 (0.6–1.3)
 CC+ ACEverb19 /211.1 (0.6–2.2)52 /990.7 (0.5–1.1)
  • a Adjusted for sampling fractions, age, gender, and energy intake.

  • b Alcohol intake.

  • c nd, not determined.

  • d Unstable estimate because of small numbers.