Table 3

Stratified analyses of MPO polymorphism and lung cancer in selected subgroupsa

Crude ORAdjusted ORb
A/A vs. G/GA/G vs. G/GA/A + A/G vs. G/GA/A vs. G/GA/G vs. G/GA/A + A/G vs. G/G
Age ≤ 59c1.22 (0.6–2.4)0.92 (0.7–1.3)0.96 (0.7–1.3)1.14 (0.5–2.4)0.85 (0.6–1.2)0.88 (0.6–1.2)
 Casesn = 28216/171d95/171e111/171f
 Controlsn = 54925/327197/327222/327
Age > 591.68 (0.9–3.1)1.11 (0.9–1.4)1.16 (0.9–1.5)1.10 (0.5–2.2)1.10 (0.8–1.5)1.10 (0.8–1.4)
 Casesn = 70631/427248/427279/427
 Controlsn = 57916/370193/370209/370
Females1.27 (0.7–2.4)0.97 (0.7–1.3)0.99 (0.8–1.3)1.29 (0.6–2.8)0.99 (0.7–1.4)1.01 (0.7–1.4)
 Casesn = 45020/273157/273177/273
 Controlsn = 60321/365217/365238/365
Males1.38 (0.8–2.5)1.10 (0.8–1.4)1.13 (0.9–1.4)1.08 (0.5–2.2)1.05 (0.8–1.4)1.05 (0.8–1.4)
 Casesn = 53827/325186/325213/325
 Controlsn = 52520/332173/332193/325
Current smokers2.19 (0.9–5.2)1.16 (0.8–1.7)1.25 (0.9–1.8)2.38 (0.9–6.2)1.25 (0.8–1.9)1.34 (0.9–2.0)
 Casesn = 40626/234146/234172/234
 Controlsn = 2197/13874/13881/138
Former smokers0.80 (0.4–1.5)1.01 (0.8–1.3)0.98 (0.8–1.3)0.72 (0.4–1.5)0.95 (0.7–1.3)0.92 (0.7–1.2)
 Casesn = 51919/322178/322197/322
 Controlsn = 50623/312171/312194/312
Nonsmokersn/a0.77 (0.4–1.4)0.79 (0.5–1.4)n/a0.79 (0.4–1.4)0.82 (0.5–1.4)
 Casesn = 632/4219/4221/42
 Controlsn = 40311/247145/247156/247
Adenocarcinomas1.39 (0.8–2.4)1.06 (0.8–1.3)1.09 (0.9–1.4)1.36 (0.8–2.5)1.03 (0.8–1.3)1.06 (0.8–1.4)
 Casesn = 47323/283167/283190/283
 Controlsn = 112841/697390/697431/697
Squamous cell carcinoma2.02 (1.1–3.8)d1.19 (0.9–1.6)1.27 (0.95–1.7)1.82 (0.8–4.1)1.33 (0.9–1.9)1.38 (0.96–2.0)
 Casesn = 22515/12684/12699/126
 Controlsn = 112841/697390/697431/697
  • a P > 0.05 unless otherwise indicated. n/a, numbers in at least one category or “cells” were too small (<10) for appropriate analysis.

  • b Adjusted analyses include covariates for age, gender, SR-PY, smoking status, and time since smoking cessation.

  • c Median age of controls.

  • d Number of A/A/number of G/G.

  • e Number of A/G/number of G/G.

  • f Number of A/A + A/G/number of G/G.