Table 5

ORs and 95% CI for colon cancer in relation to MTHFR codon 677 genotypes, total folate intake, and supplement use in African-American and white participants

MTHFR 677 genotypeFolate intakeAfrican AmericansWhites
Cases/controlsORa (95% CI)Cases/controlsORa (95% CI)
CC+ CT≥400b76 /113Reference115 /248Reference
TT≥400b2 /30.9 (0.1–6.0)c12 /261.1 (0.5–2.2)
CC+ CT<400b163 /2091.4 (1.0–2.1)167 /2391.7 (1.3–2.3)
TT<400b1 /30.7 (0.1–6.9)c12 /251.2 (0.6–2.5)
CC≥40063 /96Reference57 /135Reference
TT+ CT≥40015 /201.3 (0.6–2.8)70 /1391.3 (0.8–2.0)
CC<400133 /1681.5 (1.0–2.3)86 /1291.8 (1.2–2.8)
TT+ CT<40031 /441.3 (0.7–2.4)93 /1351.9 (1.3–2.9)
CC+ CTYesd58 /87Reference96 /204Reference
TTYesd0 /2nde11 /221.1 (0.5–2.4)
CC+ CTNod181 /2351.1 (0.7–1.6)186 /2831.4 (1.1–2.0)
TTNod3 /41.0 (0.2–4.9)c13 /291.0 (0.5–2.1)
CCYesd48 /71Reference48 /106Reference
TT+ CTYesd10 /180.9 (0.4–2.1)59 /1201.1 (0.7–1.8)
CCNod148 /1931.1 (0.7–1.7)95 /1581.4 (0.9–2.1)
TT+ CTNod36 /461.1 (0.6–2.0)104 /1541.6 (1.0–2.4)
  • a Adjusted for sampling fractions, age, gender, and energy intake.

  • b Total folate (μg/day).

  • c Unstable estimate because of small numbers.

  • d Dietary supplement use.

  • e nd, not determined.