Table 3

ORs and 95% CI for colon cancer in relation to MTHFR codon 677 and 1298 genotypes among all participants, African Americans and whites

Overall ORa (95% CI)African Americans ORb (95% CI)Whites ORb (95% CI)
MTHFR 677 genotype
 CCReferenceReferenceReference
 CT1.1 (0.9–1.4)1.0 (0.6–1.5)1.2 (0.9–1.6)
 TT0.8 (0.5–1.4)0.8 (0.2–3.1)0.9 (0.5–1.5)
 TT+ CT versus CC as reference group1.1 (0.8–1.3)1.0 (0.6–1.5)1.1 (0.8–1.5)
 TT versus CC+ CT as reference group0.8 (0.5–1.3)0.8 (0.2–3.1)0.8 (0.5–1.4)
MTHFR 1298 genotype
 AAReferenceReferenceReference
 AC0.9 (0.7–1.2)1.1 (0.8–1.6)0.9 (0.6–1.1)
 CC0.6 (0.4–0.9)0.8 (0.3–2.1)0.5 (0.3–0.8)
 AC+ CC versus AA as reference group0.9 (0.7–1.1)1.1 (0.7–1.5)0.8 (0.6–1.0)
 CC versus AA+ AC as reference group0.6 (0.4–0.9)0.8 (0.3–2.0)0.5 (0.3–0.9)
  • a Adjusted for sampling fractions, age, gender, and race.

  • b Adjusted for sampling fractions, age, and gender.