Table 4

Results of meta-analyses of lung cancer risk associated with MPO genotype

SubjectsTotalMPO genotype
G/GG/AA/AG/A or A/A
All (10 studies)
 Cases/controls2686/33251687/2013878/1128121/184999/1312
 Meta-OR (95% CI)1 (Reference)0.89 (0.73–1.08)0.86 (0.67–1.10)0.86 (0.71–1.03)
P0.240.220.10
All but those from the study by Xu et al.
 Cases/controls1698/21971089/1316535/73874/143609/881
 Meta-OR (95% CI)1 (Reference)0.87 (0.69–1.09)0.68 (0.50–0.93)0.83 (0.67–1.01)
P0.220.020.07
All Caucasians (7 studies)
 Cases/controls2341/28151472/1696765/970104/149869/1119
 Meta-OR (95% CI)1 (Reference)0.84 (0.67–1.06)0.86 (0.66–1.13)0.82 (0.66–1.02)
P0.150.290.07
Caucasians, except those from the study by Xu et al.
 Cases/controls1353/1687874/999422/58057/108479/688
 Meta-OR (95% CI)1 (Reference)0.80 (0.60–1.06)0.65 (0.45–0.92)0.77 (0.60–0.98)
P0.120.020.03