Table 3

Summary of case-control studies of lung cancer and MPO genotype

StudyCasesControlsCrude ORa (95% CI)
Total% of G/A% of A/ASourceTotal% of G/A% of A/AFor G/A genotypeFor A/A genotypeFor (G/A + A/A) genotypes
London et al.b (7)USA18232.42.2Healthy45931.27.80.97 (0.67–1.41)0.26 (0.09–0.75)0.83 (0.58–1.19)
London et al.c (7)USA15747.17.6Healthy24441.09.41.26 (0.83–1.92)0.89 (0.42–1.90)1.19 (0.77–1.78)
Cascorbi et al.b (8)Germany19625.03.1Hospital19638.32.00.54 (0.35–0.84)1.25 (0.34–4.52)0.58 (0.38–0.88)
Le Marchand et al.b (9)USA13528.25.2Healthy17133.98.80.71 (0.43–1.17)0.51 (0.20–1.30)0.67 (0.42–1.07)
Le Marchand et al.d (9)USA10821.30.9Healthy16325.14.30.77 (0.43–1.38)0.20 (0.02–1.62)0.68 (0.39–1.20)
Le Marchand et al.e (9)USA8020.05.0Healthy10316.54.81.27 (0.59–2.72)1.08 (0.28–4.19)1.23 (0.62–2.45)
Misra et al.b (11)Finland31534.35.1Healthy31139.86.81.39 (0.98–1.96)0.82 (0.42–1.62)1.27 (0.92–1.76)
Schabath et al.b (16)USA37533.63.7Healthy37841.55.10.69 (0.51–0.93)0.63 (0.31–1.29)0.68 (0.51–0.91)
Xu et al.b (this issue)USA98834.74.8Healthy112834.63.61.03 (0.85–1.23)1.34 (0.87–2.06)1.05 (0.89–1.26)
Present studybFrance15028.06.7Hospital17236.67.60.65 (0.40–1.06)0.75 (0.32–1.80)0.67 (0.43–1.05)
  • a G/G genotype as reference category, 95% CI of ORs computed by Woolf’s method.

  • b Caucasians.

  • c African-Americans.

  • d Japanese.

  • e Hawaiians.