Table 1

Association of Waf-1 polymorphism with breast cancer

Population (n)GenotypeF(S)bHWc
R/RaR/SS/S
Caucasian
 Controls (187)155 (83)d27 (14)5 (3)0.100.01
 Cases (93)82 (88)7 (8)4 (4)0.082 × 10−6
χ2e = 3.16, P = 0.21
African-American
 Controls (65)36 (55)23 (35)6 (9)0.270.42
 Cases (37)13 (35)20 (54)4 (11)0.380.36
χ2 = 4.02, P = 0.13
Latinas
 Controls (75)46 (61)22 (29)7 (9)0.240.09
 Cases (30)17 (57)9 (30)4 (13)0.280.15
χ2 = 0.41, P = 0.82
  • a R/R = homozygous arginine variant, R/S = heterozygote, S/S = homozygous serine variant.

  • b F(S) = frequency of serine variant.

  • c HW = Hardy-Weinberg equilibrium, P.

  • d Numbers in parentheses = percent.

  • e χ2 difference, df = 2. Comparing control groups (χ2 difference). Caucasian vs. African-American: χ2 = 20.23, P = 0.001, df = 2. Caucasian vs. Latinas χ2 = 14.78, P = 0.001, df = 2. Latinas vs. African American: χ2 = 0.61, P = 0.74, df = 2.