Table 5

Interactions between smoking status and quartiles of serum IGF-I, IGFBP-3, and IGF-1/IGFBP-3 on odds of lung cancera

QuartileSmoking status (N = number of cases/number of controls)
Quit 6+ years ago (N = 25/84)Quit < 6 years ago (N = 30/68)Current smokers (N = 104/145)
NORCIPNORCIPNORCIP
IGF-I
 Q12/211.007/151.0029/371.00
 Q29/202.910.51–16.660.236/190.840.20–3.590.8121/410.660.30–1.460.31
 Q35/212.210.35–14.080.408/180.740.18–3.000.6729/340.910.41–2.010.82
 Q49/222.210.38–12.840.389/160.990.22–4.360.9925/330.870.41–1.860.72
 Trend1.120.70–1.780.640.980.61–1.580.940.990.78–1.260.92
IGFBP-3
 Q15/231.005/161.0020/331.00
 Q26/171.580.38–6.560.534/151.270.21–7.520.7929/431.260.55–2.880.58
 Q38/260.920.22–3.830.916/180.850.17–4.240.8523/321.550.62–3.890.35
 Q46/180.930.21–4.010.9215/193.220.82–12.700.0932/371.910.82–4.430.13
 Trend0.940.59–1.490.781.470.95–2.290.081.240.95–1.610.11
IGF-I:IGFBP-3
 Q14/151.0010/191.0032/401.00
 Q27/210.930.20–4.240.927/150.630.16–2.430.5021/340.680.30–1.510.34
 Q35/210.760.15–3.850.744/150.390.09–1.780.2325/390.580.25–1.360.21
 Q49/271.010.23–4.450.999/190.560.15–2.050.3826/320.640.27–1.480.29
 Trend1.000.64–1.571.000.820.54–1.250.350.860.65–1.130.26
  • a Conditional logistic regression models with adjustment for body mass index, pack-years of smoking, and exposure population.