Table 4

Estimated risk of postmenopausal breast cancer associated with glucose metabolism and IGF-I factors by strata of BMIa

Tertiles of VariablesLOW BMI ≤26HIGH BMI >26
IIIIIIIIIIIIPb
Glucose
 RR (95% CI)1.001.90 (0.80–4.54)0.86 (0.26–2.80)1.002.24 (0.70–7.16)2.05 (0.62–6.76)0.61
 No. case/control12/4818/415/275/3613/4211/44
Insulin
 RR (95% CI)1.000.36 (0.13–0.98)0.65 (0.23–1.79)1.001.20 (0.30–4.73)2.16 (0.62–7.52)0.06
 No. case/control21/487/417/274/279/4616/49
IGF-I
 RR (95% CI)1.000.68 (0.26–1.78)0.55 (0.20–1.48)1.001.18 (0.43–3.27)1.31 (0.45–3.80)0.14
 No. case/control14/3511/3710/409/4211/449/36
Free IGF-I
 RR (95% CI)1.000.40 (0.14–1.16)0.58 (0.20–1.68)1.002.40 (0.69–8.28)5.5 (1.61–18.71)0.003
 No. case/control14/319/4212/435/5210/4014/30
IGFBP-1
 RR (95% CI)1.000.73 (0.24–2.25)1.36 (0.49–3.78)1.000.62 (0.23–1.67)0.59 (0.18–1.88)0.03
 No. case/control7/259/4319/4815/539/425/27
IGFBP-2
 RR (95% CI)1.001.14 (0.39–3.31)1.40 (0.52–3.74)1.000.68 (0.26–1.76)0.58 (0.19–1.80)0.02
 No. case/control9/369/3517/4513/4310/476/32
IGFBP-3
 RR (95% CI)1.000.84 (0.32–2.18)0.88 (0.33–2.36)1.001.05 (0.38–2.93)0.78 (0.26–2.29)0.16
 No. case/control12/3612/3911/4110/4211/418/39
  • a Point estimates were adjusted for age and reproductive variables.

  • b Ps for interactive terms of each variable with BMI.