Table 3

Estimated risks (RR) of postmenopausal breast cancer and 95% confidence limits by serum levels of fasting glucose, insulin, IGF-I, and IGFBPs

IaIIIIIIVP for trend
Glucose
 Crude RR (95% CI)1.001.77 (0.79–3.95)2.23 (0.93–5.37)1.27 (0.49–3.26)0.52
 Adjusted RR (95% CI)b1.001.92 (0.83–4.42)2.65 (1.06–6.66)1.63 (0.59–4.46)0.23
 No. case/control11/6121/6620/5512/56
 Quartile cut-off (ng/ml)≤71>71–≤79>79–≤86>86
Insulin
 Crude RR (95% CI)1.000.56 (0.24–1.30)0.58 (0.25–1.33)0.69 (0.31–1.51)0.42
 Adjusted RR (95% CI)b1.000.56 (0.23–1.37)0.59 (0.25–1.40)0.85 (0.36–2.00)0.76
 No. case/control21/6013/5914/6016/59
 Quartile cut-off (mIU/l)≤6.09>6.09–≤8.62>8.62–≤12.53>12.53
IGF-I
 Crude RR (95% CI)1.000.93 (0.43–2.00)0.95 (0.45–2.01)0.56 (0.24–1.78)0.21
 Adjusted RR (95% CI)b1.001.04 (0.46–2.33)1.04 (0.48–2.25)0.58 (0.24–1.36)0.25
 No. case/control19/6017/5918/6010/59
 Quartile cut-off (ng/ml)≤93.36>93.36–≤127.53>122.53–≤161.14>161.14
Free IGF-I
 Crude RR (95% CI)1.000.66 (0.28–1.55)0.71 (0.29–1.74)1.41 (0.61–3.23)0.28
 Adjusted RR (95% CI)b1.000.61 (0.25–1.51)0.68 (0.27–1.70)1.39 (0.59–3.28)0.30
 No. case/control17/5812/6411/5524/61
 Quartile cut-off (ng/ml)≤0.79>0.79–≤1.03>1.03–≤1.39>1.39
IGFBP-1
 Crude RR (95% CI)1.001.63 (0.73–3.62)0.95 (0.40–2.26)1.17 (0.81–3.87)0.33
 Adjusted RR (95% CI)b1.001.54 (0.66–3.62)0.85 (0.34–2.13)1.70 (0.70–4.15)0.50
 No. case/control12/6019/5911/6022/59
 Quartile cut-off (ng/ml)≤22.99>22.99–≤34.89>34.89–≤46.23>46.23
IGFBP-2
 Crude RR (95% CI)1.000.85 (0.39–1.85)0.20 (0.06–0.64)1.07 (0.52–2.21)0.85
 Adjusted RR (95% CI)b1.000.92 (0.40–2.09)0.19 (0.06–0.63)0.87 (0.39–1.92)0.36
 No. case/control20/6016/595/6023/59
 Quartile cut-off (ng/ml)≤264.69>264.69–≤394.995>394.995–≤517.04>517.04
IGFBP-3
 Crude RR (95% CI)1.000.82 (0.39–1.73)0.89 (0.62–1.86)0.69 (0.30–1.60)0.46
 Adjusted RR (95% CI)b1.000.78 (0.35–1.71)0.85 (0.39–1.84)0.73 (0.30–1.74)0.53
 No. case/control17/5812/6411/5524/61
 Quartile cut-off (ng/ml)≤3167>3167–≤3676.5>3676.5–≤4266>4266
  • a Reference category.

  • b Adjusted for age, BMI, social and economic status, and reproductive variables.