Table 2

Estimated risks (RR) of premenopausal breast cancer and 95% confidence limits by serum levels of fasting glucose, insulin, IGF-I, and IGFBPs

IaIIIIIIVP for trend
Glucose
 Crude RR (95% CI)1.001.11 (0.50–2.46)1.13 (0.49–2.58)2.41 (1.06–5.48)0.04
 Adjusted RR (95% CI)b1.001.09 (0.48–2.44)1.21 (0.51–2.85)2.76 (1.18–6.46)0.02
 No. case/control15/7314/6314/6626/63
 Quartile cut-off (mg/dl)≤71>71–≤78>78–≤84>84
Insulin
 Crude RR (95% CI)1.001.12 (0.49–2.55)1.58 (0.75–3.30)1.32 (0.60–2.90)0.32
 Adjusted RR (95% CI)b1.001.22 (0.52–2.87)1.78 (0.81–3.90)1.72 (0.71–4.15)0.14
 No. case/control16/7613/5722/6618/66
 Quartile cut-off (mIU/ml)≤5.49>5.49–≤7.60>7.60–≤10.96>10.96
IGF-I
 Crude RR (95% CI)1.002.30 (0.92–5.74)3.22 (1.30–7.98)2.75 (1.04–7.28)0.03
 Adjusted RR (95% CI)b1.002.3 (0.91–5.83)3.66 (1.45–9.27)3.12 (1.13–8.60)0.01
 No. case/control8/6718/6624/6619/66
 Quartile cut-off (ng/ml)≤115.17>115.17–≤149.36>149.36–≤199.10>199.10
Free IGF-I
 Crude RR (95% CI)1.000.80 (0.34–1.85)1.65 (0.78–3.67)1.40 (0.58–3.36)0.22
 Adjusted RR (95% CI)b1.000.86 (0.37–7.01)1.77 (0.82–3.82)1.55 (0.63–3.80)0.16
 No. case/control16/7111/6223/6619/66
 Quartile cut-off (ng/ml)≤0.64>0.64–≤0.90>0.90–≤1.52>1.52
IGFBP-1
 Crude RR (95% CI)1.001.13 (0.54–2.33)0.83 (0.36–1.87)1.10 (0.50–7.42)0.97
 Adjusted RR (95% CI)b1.001.11 (0.52–2.37)0.74 (0.30–1.77)0.96 (0.39–2.38)0.76
 No. case/control17/6719/6614/6619/66
 Quartile cut-off (ng/ml)≤16.59>16.59–≤24.48>24.48–≤40.93>40.93
IGFBP-2
 Crude RR (95% CI)1.000.72 (0.34–1.53)0.96 (0.46–1.98)0.79 (0.34–1.82)0.73
 Adjusted RR (95% CI)b1.000.67 (0.30–1.46)0.85 (0.38–1.89)0.66 (0.26–1.64)0.48
 No. case/control20/6714/6619/6616/66
 Quartile cut-off (ng/ml)≤282.03>282.03–≤381.990>381.990–≤519.18>519.18
IGFBP-3
 Crude RR (95% CI)1.001.06 (0.44–2.56)2.09 (0.91–4.79)2.30 (0.98–5.41)0.02
 Adjusted RR (95% CI)b1.001.05 (0.43–2.56)2.12 (0.91–4.95)2.31 (0.97–5.53)0.02
 No. case/control12/6712/6622/6723/65
 Quartile cut-off (ng/ml)≤3091>3091–≤3482>3482–≤3986>3986
  • a I, Reference category.

  • b Adjusted for age, BMI, social and economic status, and reproductive variables.