Table 2

Joint association of alcohol and folate (including supplements) with risk of hormone receptor-specific postmenopausal breast cancera

Daily intakesAlcohol (g)cER+ER−PR+PR−
Folate (μg)bndRR (95% CI)ndRR (95% CI)ndRR (95% CI)ndRR (95% CI)
>35103291.00 (ref)501.00 (ref)2701.00 (ref)881.00 (ref)
≤41500.97 (0.79–1.19)331.32 (0.83–2.11)1230.99 (0.79–1.25)481.04 (0.72–1.52)
>41211.01 (0.80–1.26)231.11 (0.64–1.93)981.02 (0.80–1.32)391.05 (0.70–1.58)
252–35101520.86 (0.70–1.06)180.65 (0.36–1.14)1280.88 (0.70–1.10)300.62 (0.40–0.97)
≤4791.02 (0.78–1.32)141.12 (0.60–2.09)671.04 (0.78–1.38)211.02 (0.63–1.66)
>4641.04 (0.78–1.39)191.76 (0.98–3.15)541.14 (0.81–1.53)261.37 (0.85–2.20)
≤25101720.99 (0.80–1.22)331.16 (0.71–1.90)1471.05 (0.83–1.32)541.06 (0.72–1.55)
≤4681.13 (0.85–1.50)161.54 (0.83–2.87)491.07 (0.77–1.48)281.48 (0.93–2.36)
>4561.04 (0.76–1.42)192.14 (1.18–3.85)531.22 (0.88–1.70)191.18 (0.69–2.02)
  • a All models account for age, caloric intake, education, family history of breast cancer, age at menarche, age at menopause, oral contraceptive use, hormone replacement therapy, parity, age at first birth, body mass index, waist-to-hip ratio, height, weight, body mass index at age 18, smoking status, physical activity, and methionine.

  • b Categories are based on 50/25/25 split of folate intake in the entire cohort at risk.

  • c Alcohol categories are based on a median split among drinkers.

  • d n indicates number of breast cancer events.