Table 1

Association of alcohol and folate with risk of hormone receptor-specific breast cancera

Daily intakebER+ER−Missing ERPR+PR−Missing PR
RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)
Folate with supplements (μg)
 ≤ 1861.04 (0.82–1.31)1.14 (0.66–1.95)1.60 (1.11–2.29)1.10 (0.84–1.42)1.04 (0.68–1.59)1.41 (1.00–1.99)
 187–2701.07 (0.91–1.26)1.37 (0.96–1.96)1.22 (0.94–1.59)1.14 (0.96–1.37)1.11 (0.83–1.50)1.16 (0.90–1.48)
 271–3510.89 (0.76–1.06)0.80 (0.53–1.20)1.02 (0.79–1.32)0.88 (0.73–1.06)0.87 (0.64–1.18)1.00 (0.79–1.27)
 > 3511.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
Folate without supplements (μg)
 ≤1721.06 (0.82–1.36)1.21 (0.69–2.13)1.70 (1.16–2.50)1.14 (0.86–1.51)0.98 (0.62–1.54)1.55 (1.08–2.21)
 173–2391.02 (0.85–1.23)1.05 (0.69–1.60)1.02 (0.76–1.38)1.08 (0.88–1.32)0.99 (0.72–1.38)0.95 (0.72–1.26)
 240–2940.92 (0.78–1.10)0.99 (0.67–1.46)1.10 (0.85–1.44)1.02 (0.84–1.22)0.75 (0.54–1.04)1.06 (0.83–1.35)
 > 2941.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
Alcohol (g)
 01.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
 ≤41.06 (0.91–1.22)1.40 (1.00–1.96)0.96 (0.76–1.22)1.04 (0.89–1.23)1.24 (0.95–1.62)1.01 (0.81–1.26)
 > 41.07 (0.90–1.26)1.64 (1.14–2.35)1.02 (0.79–1.32)1.12 (0.93–1.34)1.28 (0.96–1.71)1.00 (0.79–1.28)
  • a All models account for age, caloric intake, education, family history of breast cancer, age at menarche, age at menopause, oral contraceptive use, hormone replacement therapy, parity, age at first birth, body mass index, waist-to-hip ratio, height, weight, body mass index at age 18, smoking status, physical activity, and methionine.

  • b Folate categories reflect lowest 10th, 11th–30th, 31st–50th, and upper 50th (ref) percentiles. Alcohol categories are based on a median split among drinkers.