Table 2

Associations of XRCC1 polymorphisms with prostate cancer

GenotypeCases (n = 76)Controls (n = 182)OR adjusteda (95% CI)P
No. (%)No. (%)
Codon 194
Arg/Arg67 (88)152 (84)1
Arg/Trp9 (12)28 (15)0.8 (0.4–1.8)0.56
Trp/Trp0 (0)2 (1)NDbNDb
Arg/Arg67 (88)152 (84)1
Arg/Trp + Trp/Trp9 (12)30 (16)0.7 (0.3–1.6)0.45
 Allele frequency Trp5.9%8.8%
Codon 280
Arg/Arg66 (87)164 (90)1
Arg/His10 (13)18 (10)1.5 (0.7–3.6)0.31
His/His0 (0)0 (0)
Allele frequency His6.6%4.9%
Codon 399
Arg/Arg37 (49)77 (42)1
Arg/Gln30 (39)78 (43)0.8 (0.5–1.4)0.45
Gln/Gln9 (12)27 (15)0.7 (0.3–1.6)0.38
Arg/Arg37 (49)77 (42)1
Arg/Gln + Gln/Gln39 (51)105 (58)0.8 (0.5–1.3)0.34
Allele frequency Gln31.6%36.3%
  • a Adjusted for age and ethnicity.

  • b ND, not defined, because of zero counts in one cell.