Table 3

Influence of nicotine and its metabolites, CYP1A2 and NAT2 phenotypes and GSTM1 and GSTT1 genotypes on urinary mutagenicity in 96 smokers: results of multiple linear regression analysis

Nicotine and its metabolitesCYP1A2NAT2GSTM1GSTT1
t 4.513.091.280.730.88
P <0.0010.0030.2050.4670.382
Partial r216.7%7.9%1.3%0.4%0.3%
  • a Coefficients of regression (b), corresponding standard error (SE(b)), t test of partial significance, and partial explained variance (r2) were estimated for each term included in the model. F = 6.31, P < 0.001.