Table 1

Characteristics of smoking sample population

Characteristics
No. of subjects97
Gender
 Female41
 Male56
Age (yrs)
 Mean ± SD38 ± 12
 Range18–69
Cigarettes/day
 Mean ± SD18 ± 8
 Range7–50
Nicotine and its metabolites (mg/mmol creatinine)
 Mean ± SD0.75 ± 0.54
 Range0.07–3.56
Urinary mutagenicity (revertants/mmol creatinine)
 Mean ± SD1784 ± 1425
 Range0–6709
CYP1A2 activitya
 Mean ± SD5.89 ± 5.93
 Range1.68–15.32
 PM48 (50%)
 EM49 (50%)
NAT2 activityb
 Mean ± SD0.24 ± 0.02
 Range0.05–0.62
 Slow69 (71%)
 Rapid28 (29%)
GSTM1 genotypes
 Active42 (43%)
 *0/*055 (57%)
GSTT1 genotypes
 Active72 (75%)
 *0/*024 (25%)
  • a An (AFMU + 1X + 1U)/17U ratio < and ≥ 5.5 (median value) defined PM and EM CYP1A2 phenotypes.

  • b An AFMU/(AFMU + 1X + 1U) ratio < and ≥ 0.3 defined NAT2 slow and rapid acetylators.